Ras-related GTP-binding protein C (RRAGC)

About Ras-related GTP-binding protein C

Ras-related GTP-binding protein C (RRAGC) is a protein from Homo sapiens identified by UniProt accession Q9HB90, 399 residues long. MolForge cross-references it against 0 known binders and 167 disease associations.

Target properties

Protein name	Ras-related GTP-binding protein C
UniProt accession	Q9HB90
Gene	RRAGC
Organism	Homo sapiens
Length	399 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (167)

Diseases linked to this target (Open Targets).

Long-Olsen-Distelmaier syndrome · score 0.63
non-Hodgkins lymphoma · score 0.37
neutrophil count · score 0.32
leukocyte count · score 0.31
mathematical ability · score 0.30
lymphoma · score 0.28
lung adenocarcinoma · score 0.27
myeloid white cell count · score 0.24
endometrial cancer · score 0.23
hematocrit · score 0.23

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9HB90-F1	alphafold	PREDICTED	68.77	—

Amino-acid sequence (399 residues)

MSLQYGAEET PLAGSYGAAD SFPKDFGYGV EEEEEEAAAA GGGVGAGAGG GCGPGGADSS KPRILLMGLR RSGKSSIQKV VFHKMSPNET LFLESTNKIY KDDISNSSFV NFQIWDFPGQ MDFFDPTFDY EMIFRGTGAL IYVIDAQDDY MEALTRLHIT VSKAYKVNPD MNFEVFIHKV DGLSDDHKIE TQRDIHQRAN DDLADAGLEK LHLSFYLTSI YDHSIFEAFS KVVQKLIPQL PTLENLLNIF ISNSGIEKAF LFDVVSKIYI ATDSSPVDMQ SYELCCDMID VVIDVSCIYG LKEDGSGSAY DKESMAIIKL NNTTVLYLKE VTKFLALVCI LREESFERKG LIDYNFHCFR KAIHEVFEVG VTSHRSCGHQ TSASSLKALT HNGTPRNAI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards