About T-lymphocyte surface antigen Ly-9
T-lymphocyte surface antigen Ly-9 (LY9) is a protein
from Homo sapiens identified by UniProt accession
Q9HBG7, 655 residues long.
MolForge cross-references it against 0 known binders and
102 disease associations.
Target properties
| Protein name | T-lymphocyte surface antigen Ly-9 |
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| UniProt accession | Q9HBG7 |
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| Gene | LY9 |
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| Organism | Homo sapiens |
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| Length | 655 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (102)
Diseases linked to this target (Open Targets).
- lymphocyte count · score 0.42
- lymphocyte percentage of leukocytes · score 0.37
- blood protein measurement · score 0.33
- lymphocyte:monocyte ratio · score 0.27
- neutrophil-to-lymphocyte ratio · score 0.27
- eosinophil percentage of leukocytes · score 0.24
- monocyte percentage of leukocytes · score 0.22
- T-lymphocyte surface antigen Ly-9 measurement · score 0.21
- CINCA syndrome · score 0.18
- neutrophil percentage of leukocytes · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9HBG7-F1 | alphafold | PREDICTED | 66.07 | — |
Amino-acid sequence (655 residues)
MVAPKSHTDD WAPGPFSSKP QRSQLQIFSS VLQTSLLFLL MGLRASGKDS APTVVSGILG GSVTLPLNIS VDTEIENVIW IGPKNALAFA RPKENVTIMV KSYLGRLDIT KWSYSLCISN LTLNDAGSYK AQINQRNFEV TTEEEFTLFV YEQLQEPQVT MKSVKVSENF SCNITLMCSV KGAEKSVLYS WTPREPHASE SNGGSILTVS RTPCDPDLPY ICTAQNPVSQ RSSLPVHVGQ FCTDPGASRG GTTGETVVGV LGEPVTLPLA LPACRDTEKV VWLFNTSIIS KEREEAATAD PLIKSRDPYK NRVWVSSQDC SLKISQLKIE DAGPYHAYVC SEASSVTSMT HVTLLIYRRL RKPKITWSLR HSEDGICRIS LTCSVEDGGN TVMYTWTPLQ KEAVVSQGES HLNVSWRSSE NHPNLTCTAS NPVSRSSHQF LSENICSGPE RNTKLWIGLF LMVCLLCVGI FSWCIWKRKG RCSVPAFCSS QAEAPADTPE PTAGHTLYSV LSQGYEKLDT PLRPARQQPT PTSDSSSDSN LTTEEDEDRP EVHKPISGRY EVFDQVTQEG AGHDPAPEGQ ADYDPVTPYV TEVESVVGEN TMYAQVFNLQ GKTPVSQKEE SSATIYCSIR KPQVVPPPQQ NDLEIPESPT YENFT
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