About Rho-related GTP-binding protein RhoF
Rho-related GTP-binding protein RhoF (RHOF) is a protein
from Homo sapiens identified by UniProt accession
Q9HBH0, 211 residues long.
MolForge cross-references it against 0 known binders and
108 disease associations.
Target properties
| Protein name | Rho-related GTP-binding protein RhoF |
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| UniProt accession | Q9HBH0 |
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| Gene | RHOF |
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| Organism | Homo sapiens |
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| Length | 211 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (108)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.69
- platelet count · score 0.46
- neutrophil count · score 0.44
- platelet crit · score 0.44
- leukocyte count · score 0.40
- platelet component distribution width · score 0.38
- mean corpuscular volume · score 0.38
- erythrocyte count · score 0.37
- Immature Reticulocyte Fraction Measurement · score 0.34
- reticulocyte measurement · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9HBH0-F1 | alphafold | PREDICTED | 91.61 | — |
Amino-acid sequence (211 residues)
MDAPGALAQT AAPGPGRKEL KIVIVGDGGC GKTSLLMVYS QGSFPEHYAP SVFEKYTASV TVGSKEVTLN LYDTAGQEDY DRLRPLSYQN THLVLICYDV MNPTSYDNVL IKWFPEVTHF CRGIPMVLIG CKTDLRKDKE QLRKLRAAQL EPITYMQGLS ACEQIRAALY LECSAKFREN VEDVFREAAK VALSALKKAQ RQKKRRLCLL L
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