Retinol dehydrogenase 14 (RDH14)

About Retinol dehydrogenase 14

Retinol dehydrogenase 14 (RDH14) is a protein from Homo sapiens identified by UniProt accession Q9HBH5, 336 residues long. MolForge cross-references it against 0 known binders and 39 disease associations.

Target properties

Protein name	Retinol dehydrogenase 14
UniProt accession	Q9HBH5
Gene	RDH14
Organism	Homo sapiens
Length	336 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (39)

Diseases linked to this target (Open Targets).

vital capacity · score 0.41
forced expiratory volume · score 0.38
glomerular filtration rate · score 0.37
urate measurement · score 0.35
creatinine measurement · score 0.33
peak expiratory flow · score 0.32
cortical thickness · score 0.31
type 2 diabetes mellitus · score 0.31
brain measurement · score 0.31
cystatin C measurement · score 0.31

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9HBH5-F1	alphafold	PREDICTED	87.89	—

Amino-acid sequence (336 residues)

MAVATAAAVL AALGGALWLA ARRFVGPRVQ RLRRGGDPGL MHGKTVLITG ANSGLGRATA AELLRLGARV IMGCRDRARA EEAAGQLRRE LRQAAECGPE PGVSGVGELI VRELDLASLR SVRAFCQEML QEEPRLDVLI NNAGIFQCPY MKTEDGFEMQ FGVNHLGHFL LTNLLLGLLK SSAPSRIVVV SSKLYKYGDI NFDDLNSEQS YNKSFCYSRS KLANILFTRE LARRLEGTNV TVNVLHPGIV RTNLGRHIHI PLLVKPLFNL VSWAFFKTPV EGAQTSIYLA SSPEVEGVSG RYFGDCKEEE LLPKAMDESV ARKLWDISEV MVGLLK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards