Arsenite methyltransferase (AS3MT)

About Arsenite methyltransferase

Arsenite methyltransferase (AS3MT) is a protein from Homo sapiens identified by UniProt accession Q9HBK9, 375 residues long. MolForge cross-references it against 0 known binders and 143 disease associations.

Target properties

Protein name	Arsenite methyltransferase
UniProt accession	Q9HBK9
Gene	AS3MT
Organism	Homo sapiens
Length	375 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (143)

Diseases linked to this target (Open Targets).

pulse pressure measurement · score 0.35
urinary arsenic measurement · score 0.33
alcohol drinking · score 0.32
appendicular lean mass · score 0.31
sex hormone-binding globulin measurement · score 0.29
Red cell distribution width · score 0.29
calcium measurement · score 0.29
alcohol consumption measurement · score 0.29
schizophrenia · score 0.28
mean corpuscular hemoglobin concentration · score 0.28

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9HBK9-F1	alphafold	PREDICTED	86.95	—

Amino-acid sequence (375 residues)

MAALRDAEIQ KDVQTYYGQV LKRSADLQTN GCVTTARPVP KHIREALQNV HEEVALRYYG CGLVIPEHLE NCWILDLGSG SGRDCYVLSQ LVGEKGHVTG IDMTKGQVEV AEKYLDYHME KYGFQASNVT FIHGYIEKLG EAGIKNESHD IVVSNCVINL VPDKQQVLQE AYRVLKHGGE LYFSDVYTSL ELPEEIRTHK VLWGECLGGA LYWKELAVLA QKIGFCPPRL VTANLITIQN KELERVIGDC RFVSATFRLF KHSKTGPTKR CQVIYNGGIT GHEKELMFDA NFTFKEGEIV EVDEETAAIL KNSRFAQDFL IRPIGEKLPT SGGCSALELK DIITDPFKLA EESDSMKSRC VPDAAGGCCG TKKSC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards