Popeye domain-containing protein 3 (POPDC3)

About Popeye domain-containing protein 3

Popeye domain-containing protein 3 (POPDC3) is a protein from Homo sapiens identified by UniProt accession Q9HBV1, 291 residues long. MolForge cross-references it against 0 known binders and 43 disease associations.

Target properties

Protein name	Popeye domain-containing protein 3
UniProt accession	Q9HBV1
Gene	POPDC3
Organism	Homo sapiens
Length	291 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (43)

Diseases linked to this target (Open Targets).

muscular dystrophy, limb-girdle, autosomal recessive 23 · score 0.55
autosomal recessive limb-girdle muscular dystrophy · score 0.18
blood protein measurement · score 0.14
QT interval · score 0.12
electrocardiography · score 0.08
head and neck squamous cell carcinoma · score 0.06
T wave morphology measurement · score 0.05
diet measurement · score 0.04
hepatocellular carcinoma · score 0.04
device complication · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9HBV1-F1	alphafold	PREDICTED	82.29	—

Amino-acid sequence (291 residues)

MERNSSLWKN LIDEHPVCTT WKQEAEGAIY HLASILFVVG FMGGSGFFGL LYVFSLLGLG FLCSAVWAWV DVCAADIFSW NFVLFVICFM QFVHIAYQVR SITFAREFQV LYSSLFQPLG ISLPVFRTIA LSSEVVTLEK EHCYAMQGKT SIDKLSLLVS GRIRVTVDGE FLHYIFPLQF LDSPEWDSLR PTEEGIFQVT LTAETDCRYV SWRRKKLYLL FAQHRYISRL FSVLIGSDIA DKLYALNDRV YIGKRYHYDI RLPNFYQMST PEIRRSPLTQ HFQNSRRYCD K

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards