Sperm acrosome membrane-associated protein 1 (SPACA1)

About Sperm acrosome membrane-associated protein 1

Sperm acrosome membrane-associated protein 1 (SPACA1) is a protein from Homo sapiens identified by UniProt accession Q9HBV2, 294 residues long. MolForge cross-references it against 0 known binders and 86 disease associations.

Target properties

Protein name	Sperm acrosome membrane-associated protein 1
UniProt accession	Q9HBV2
Gene	SPACA1
Organism	Homo sapiens
Length	294 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (86)

Diseases linked to this target (Open Targets).

age-related hearing impairment · score 0.29
visual perception measurement · score 0.22
neurodegenerative disease · score 0.19
azoospermia · score 0.11
male infertility with teratozoospermia due to single gene mutation · score 0.10
spermatogenic failure 42 · score 0.07
spermatogenic failure 72 · score 0.07
spermatogenic failure 18 · score 0.07
spermatogenic failure 46 · score 0.07
spermatogenic failure 27 · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9HBV2-F1	alphafold	PREDICTED	70.99	—

Amino-acid sequence (294 residues)

MSPRGTGCSA GLLMTVGWLL LAGLQSARGT NVTAAVQDAG LAHEGEGEEE TENNDSETAE NYAPPETEDV SNRNVVKEVE FGMCTVTCGI GVREVILTNG CPGGESKCVV RVEECRGPTD CGWGKPISES LESVRLACIH TSPLNRFKYM WKLLRQDQQS IILVNDSAIL EVRKESHPLA FECDTLDNNE IVATIKFTVY TSSELQMRRS SLPATDAALI FVLTIGVIIC VFIIFLLIFI IINWAAVKAF WGAKASTPEV QSEQSSVRYK DSTSLDQLPT EMPGEDDALS EWNE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards