About Adhesion G protein-coupled receptor L4
Adhesion G protein-coupled receptor L4 (ADGRL4) is a protein
from Homo sapiens identified by UniProt accession
Q9HBW9, 690 residues long.
MolForge cross-references it against 0 known binders and
139 disease associations.
Target properties
| Protein name | Adhesion G protein-coupled receptor L4 |
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| UniProt accession | Q9HBW9 |
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| Gene | ADGRL4 |
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| Organism | Homo sapiens |
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| Length | 690 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (139)
Diseases linked to this target (Open Targets).
- neutrophil count · score 0.42
- eosinophil count · score 0.42
- Red cell distribution width · score 0.41
- leukocyte count · score 0.41
- monocyte count · score 0.40
- lymphocyte count · score 0.39
- mean corpuscular volume · score 0.39
- lymphocyte percentage of leukocytes · score 0.38
- hematocrit · score 0.37
- mean platelet volume · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9HBW9-F1 | alphafold | PREDICTED | 81.01 | — |
Amino-acid sequence (690 residues)
MKRLPLLVVF STLLNCSYTQ NCTKTPCLPN AKCEIRNGIE ACYCNMGFSG NGVTICEDDN ECGNLTQSCG ENANCTNTEG SYYCMCVPGF RSSSNQDRFI TNDGTVCIEN VNANCHLDNV CIAANINKTL TKIRSIKEPV ALLQEVYRNS VTDLSPTDII TYIEILAESS SLLGYKNNTI SAKDTLSNST LTEFVKTVNN FVQRDTFVVW DKLSVNHRRT HLTKLMHTVE QATLRISQSF QKTTEFDTNS TDIALKVFFF DSYNMKHIHP HMNMDGDYIN IFPKRKAAYD SNGNVAVAFV YYKSIGPLLS SSDNFLLKPQ NYDNSEEEER VISSVISVSM SSNPPTLYEL EKITFTLSHR KVTDRYRSLC AFWNYSPDTM NGSWSSEGCE LTYSNETHTS CRCNHLTHFA ILMSSGPSIG IKDYNILTRI TQLGIIISLI CLAICIFTFW FFSEIQSTRT TIHKNLCCSL FLAELVFLVG INTNTNKLFC SIIAGLLHYF FLAAFAWMCI EGIHLYLIVV GVIYNKGFLH KNFYIFGYLS PAVVVGFSAA LGYRYYGTTK VCWLSTENNF IWSFIGPACL IILVNLLAFG VIIYKVFRHT AGLKPEVSCF ENIRSCARGA LALLFLLGTT WIFGVLHVVH ASVVTAYLFT VSNAFQGMFI FLFLCVLSRK IQEEYYRLFK NVPCCFGCLR
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