About Leucine-rich repeat-containing G-protein coupled receptor 6
Leucine-rich repeat-containing G-protein coupled receptor 6 (LGR6) is a protein
from Homo sapiens identified by UniProt accession
Q9HBX8, 967 residues long.
MolForge cross-references it against 0 known binders and
143 disease associations.
Target properties
| Protein name | Leucine-rich repeat-containing G-protein coupled receptor 6 |
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| UniProt accession | Q9HBX8 |
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| Gene | LGR6 |
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| Organism | Homo sapiens |
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| Length | 967 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (143)
Diseases linked to this target (Open Targets).
- breast carcinoma · score 0.36
- estrogen-receptor negative breast cancer · score 0.35
- Fanconi anemia · score 0.33
- heel bone mineral density · score 0.32
- blood urea nitrogen measurement · score 0.30
- bilirubin measurement · score 0.27
- acne · score 0.18
- platelet count · score 0.16
- neoplasm · score 0.10
- esophageal squamous cell carcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9HBX8-F1 | alphafold | PREDICTED | 77.38 | — |
Amino-acid sequence (967 residues)
MPSPPGLRAL WLCAALCASR RAGGAPQPGP GPTACPAPCH CQEDGIMLSA DCSELGLSAV PGDLDPLTAY LDLSMNNLTE LQPGLFHHLR FLEELRLSGN HLSHIPGQAF SGLYSLKILM LQNNQLGGIP AEALWELPSL QSLRLDANLI SLVPERSFEG LSSLRHLWLD DNALTEIPVR ALNNLPALQA MTLALNRISH IPDYAFQNLT SLVVLHLHNN RIQHLGTHSF EGLHNLETLD LNYNKLQEFP VAIRTLGRLQ ELGFHNNNIK AIPEKAFMGN PLLQTIHFYD NPIQFVGRSA FQYLPKLHTL SLNGAMDIQE FPDLKGTTSL EILTLTRAGI RLLPSGMCQQ LPRLRVLELS HNQIEELPSL HRCQKLEEIG LQHNRIWEIG ADTFSQLSSL QALDLSWNAI RSIHPEAFST LHSLVKLDLT DNQLTTLPLA GLGGLMHLKL KGNLALSQAF SKDSFPKLRI LEVPYAYQCC PYGMCASFFK ASGQWEAEDL HLDDEESSKR PLGLLARQAE NHYDQDLDEL QLEMEDSKPH PSVQCSPTPG PFKPCEYLFE SWGIRLAVWA IVLLSVLCNG LVLLTVFAGG PVPLPPVKFV VGAIAGANTL TGISCGLLAS VDALTFGQFS EYGARWETGL GCRATGFLAV LGSEASVLLL TLAAVQCSVS VSCVRAYGKS PSLGSVRAGV LGCLALAGLA AALPLASVGE YGASPLCLPY APPEGQPAAL GFTVALVMMN SFCFLVVAGA YIKLYCDLPR GDFEAVWDCA MVRHVAWLIF ADGLLYCPVA FLSFASMLGL FPVTPEAVKS VLLVVLPLPA CLNPLLYLLF NPHFRDDLRR LRPRAGDSGP LAYAAAGELE KSSCDSTQAL VAFSDVDLIL EASEAGRPPG LETYGFPSVT LISCQQPGAP RLEGSHCVEP EGNHFGNPQP SMDGELLLRA EGSTPAGGGL SGGGGFQPSG LAFASHV
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