About Aryl hydrocarbon receptor nuclear translocator 2
Aryl hydrocarbon receptor nuclear translocator 2 (ARNT2) is a protein
from Homo sapiens identified by UniProt accession
Q9HBZ2, 717 residues long.
MolForge cross-references it against 0 known binders and
148 disease associations.
Target properties
| Protein name | Aryl hydrocarbon receptor nuclear translocator 2 |
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| UniProt accession | Q9HBZ2 |
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| Gene | ARNT2 |
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| Organism | Homo sapiens |
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| Length | 717 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (148)
Diseases linked to this target (Open Targets).
- Webb-Dattani syndrome · score 0.52
- atrial fibrillation · score 0.45
- high density lipoprotein cholesterol measurement · score 0.40
- sleep duration · score 0.40
- erythrocyte count · score 0.39
- atrial flutter · score 0.38
- Septo-optic dysplasia · score 0.37
- blood protein measurement · score 0.31
- energy expenditure measurement · score 0.29
- urate measurement · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9HBZ2-F1 | alphafold | PREDICTED | 58.29 | — |
Amino-acid sequence (717 residues)
MATPAAVNPP EMASDIPGSV TLPVAPMAAT GQVRMAGAMP ARGGKRRSGM DFDDEDGEGP SKFSRENHSE IERRRRNKMT QYITELSDMV PTCSALARKP DKLTILRMAV SHMKSMRGTG NKSTDGAYKP SFLTEQELKH LILEAADGFL FVVAAETGRV IYVSDSVTPV LNQPQSEWFG STLYEQVHPD DVEKLREQLC TSENSMTGRI LDLKTGTVKK EGQQSSMRMC MGSRRSFICR MRCGNAPLDH LPLNRITTMR KRFRNGLGPV KEGEAQYAVV HCTGYIKAWP PAGMTIPEED ADVGQGSKYC LVAIGRLQVT SSPVCMDMNG MSVPTEFLSR HNSDGIITFV DPRCISVIGY QPQDLLGKDI LEFCHPEDQS HLRESFQQVV KLKGQVLSVM YRFRTKNREW MLIRTSSFTF QNPYSDEIEY IICTNTNVKQ LQQQQAELEV HQRDGLSSYD LSQVPVPNLP AGVHEAGKSV EKADAIFSQE RDPRFAEMFA GISASEKKMM SSASAAGTQQ IYSQGSPFPS GHSGKAFSSS VVHVPGVNDI QSSSSTGQNM SQISRQLNQS QVAWTGSRPP FPGQQIPSQS SKTQSSPFGI GTSHTYPADP SSYSPLSSPA TSSPSGNAYS SLANRTPGFA ESGQSSGQFQ GRPSEVWSQW QSQHHGQQSG EQHSHQQPGQ TEVFQDMLPM PGDPTQGTGN YNIEDFADLG MFPPFSE
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