Putative divalent cation/proton antiporter TMEM165 (TMEM165)

About Putative divalent cation/proton antiporter TMEM165

Putative divalent cation/proton antiporter TMEM165 (TMEM165) is a protein from Homo sapiens identified by UniProt accession Q9HC07, 324 residues long. MolForge cross-references it against 0 known binders and 161 disease associations.

Target properties

Protein name	Putative divalent cation/proton antiporter TMEM165
UniProt accession	Q9HC07
Gene	TMEM165
Organism	Homo sapiens
Length	324 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (161)

Diseases linked to this target (Open Targets).

TMEM165-congenital disorder of glycosylation · score 0.80
congenital disorder of glycosylation · score 0.51
body fat percentage · score 0.30
fat body mass · score 0.23
systolic blood pressure · score 0.18
metabolite measurement · score 0.17
C-reactive protein measurement · score 0.16
hip circumference · score 0.15
IGF-1 measurement · score 0.14
waist-hip ratio · score 0.13

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9HC07-F1	alphafold	PREDICTED	76.21	—

Amino-acid sequence (324 residues)

MAAAAPGNGR ASAPRLLLLF LVPLLWAPAA VRAGPDEDLS HRNKEPPAPA QQLQPQPVAV QGPEPARVEK IFTPAAPVHT NKEDPATQTN LGFIHAFVAA ISVIIVSELG DKTFFIAAIM AMRYNRLTVL AGAMLALGLM TCLSVLFGYA TTVIPRVYTY YVSTVLFAIF GIRMLREGLK MSPDEGQEEL EEVQAELKKK DEEFQRTKLL NGPGDVETGT SITVPQKKWL HFISPIFVQA LTLTFLAEWG DRSQLTTIVL AAREDPYGVA VGGTVGHCLC TGLAVIGGRM IAQKISVRTV TIIGGIVFLA FAFSALFISP DSGF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards