DNA dC->dU-editing enzyme APOBEC-3G (APOBEC3G)

About DNA dC->dU-editing enzyme APOBEC-3G

DNA dC->dU-editing enzyme APOBEC-3G (APOBEC3G) is a protein from Homo sapiens identified by UniProt accession Q9HC16, 384 residues long. MolForge cross-references it against 0 known binders and 166 disease associations.

Target properties

Protein name	DNA dC->dU-editing enzyme APOBEC-3G
UniProt accession	Q9HC16
Gene	APOBEC3G
Organism	Homo sapiens
Length	384 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (166)

Diseases linked to this target (Open Targets).

HIV infection · score 0.56
lymphocyte count · score 0.29
inflammatory bowel disease · score 0.13
glioblastoma multiforme · score 0.08
monocyte count · score 0.08
immune deficiency, familial variable · score 0.08
immunodeficiency 35 · score 0.07
leukocyte count · score 0.07
Chronic mucocutaneous candidosis · score 0.07
hyper-IgM syndrome type 2 · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9HC16-F1	alphafold	PREDICTED	88.56	—

Amino-acid sequence (384 residues)

MKPHFRNTVE RMYRDTFSYN FYNRPILSRR NTVWLCYEVK TKGPSRPPLD AKIFRGQVYS ELKYHPEMRF FHWFSKWRKL HRDQEYEVTW YISWSPCTKC TRDMATFLAE DPKVTLTIFV ARLYYFWDPD YQEALRSLCQ KRDGPRATMK IMNYDEFQHC WSKFVYSQRE LFEPWNNLPK YYILLHIMLG EILRHSMDPP TFTFNFNNEP WVRGRHETYL CYEVERMHND TWVLLNQRRG FLCNQAPHKH GFLEGRHAEL CFLDVIPFWK LDLDQDYRVT CFTSWSPCFS CAQEMAKFIS KNKHVSLCIF TARIYDDQGR CQEGLRTLAE AGAKISIMTY SEFKHCWDTF VDHQGCPFQP WDGLDEHSQD LSGRLRAILQ NQEN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards