About Protein lifeguard 4
Protein lifeguard 4 (TMBIM4) is a protein
from Homo sapiens identified by UniProt accession
Q9HC24, 238 residues long.
MolForge cross-references it against 0 known binders and
212 disease associations.
Target properties
| Protein name | Protein lifeguard 4 |
|---|
| UniProt accession | Q9HC24 |
|---|
| Gene | TMBIM4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 238 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (212)
Diseases linked to this target (Open Targets).
- body height · score 0.32
- BMI-adjusted hip circumference · score 0.29
- forced expiratory volume · score 0.29
- appendicular lean mass · score 0.28
- sitting height measurement · score 0.27
- neutrophil count · score 0.24
- BMI-adjusted waist-hip ratio · score 0.19
- waist-hip ratio · score 0.18
- myeloid white cell count · score 0.17
- BMI-adjusted waist circumference · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9HC24-F1 | alphafold | PREDICTED | 92.44 | — |
Amino-acid sequence (238 residues)
MADPDPRYPR SSIEDDFNYG SSVASATVHI RMAFLRKVYS ILSLQVLLTT VTSTVFLYFE SVRTFVHESP ALILLFALGS LGLIFALILN RHKYPLNLYL LFGFTLLEAL TVAVVVTFYD VYIILQAFIL TTTVFFGLTV YTLQSKKDFS KFGAGLFALL WILCLSGFLK FFFYSEIMEL VLAAAGALLF CGFIIYDTHS LMHKLSPEEY VLAAISLYLD IINLFLHLLR FLEAVNKK
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