About Echinoderm microtubule-associated protein-like 4
Echinoderm microtubule-associated protein-like 4 (EML4) is a protein
from Homo sapiens identified by UniProt accession
Q9HC35, 981 residues long.
MolForge cross-references it against 0 known binders and
373 disease associations.
Target properties
| Protein name | Echinoderm microtubule-associated protein-like 4 |
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| UniProt accession | Q9HC35 |
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| Gene | EML4 |
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| Organism | Homo sapiens |
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| Length | 981 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (373)
Diseases linked to this target (Open Targets).
- non-small cell lung carcinoma · score 0.70
- cancer · score 0.69
- neoplasm · score 0.62
- Abnormality of the skeletal system · score 0.52
- anaplastic large cell lymphoma · score 0.49
- sex hormone-binding globulin measurement · score 0.47
- lymphoma · score 0.46
- lung adenocarcinoma · score 0.44
- forced expiratory volume · score 0.43
- FEV/FVC ratio · score 0.42
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9HC35-F1 | alphafold | PREDICTED | 76.87 | — |
Amino-acid sequence (981 residues)
MDGFAGSLDD SISAASTSDV QDRLSALESR VQQQEDEITV LKAALADVLR RLAISEDHVA SVKKSVSSKG QPSPRAVIPM SCITNGSGAN RKPSHTSAVS IAGKETLSSA AKSGTEKKKE KPQGQREKKE ESHSNDQSPQ IRASPSPQPS SQPLQIHRQT PESKNATPTK SIKRPSPAEK SHNSWENSDD SRNKLSKIPS TPKLIPKVTK TADKHKDVII NQEGEYIKMF MRGRPITMFI PSDVDNYDDI RTELPPEKLK LEWAYGYRGK DCRANVYLLP TGKIVYFIAS VVVLFNYEER TQRHYLGHTD CVKCLAIHPD KIRIATGQIA GVDKDGRPLQ PHVRVWDSVT LSTLQIIGLG TFERGVGCLD FSKADSGVHL CIIDDSNEHM LTVWDWQKKA KGAEIKTTNE VVLAVEFHPT DANTIITCGK SHIFFWTWSG NSLTRKQGIF GKYEKPKFVQ CLAFLGNGDV LTGDSGGVML IWSKTTVEPT PGKGPKGVYQ ISKQIKAHDG SVFTLCQMRN GMLLTGGGKD RKIILWDHDL NPEREIEVPD QYGTIRAVAE GKADQFLVGT SRNFILRGTF NDGFQIEVQG HTDELWGLAT HPFKDLLLTC AQDRQVCLWN SMEHRLEWTR LVDEPGHCAD FHPSGTVVAI GTHSGRWFVL DAETRDLVSI HTDGNEQLSV MRYSIDGTFL AVGSHDNFIY LYVVSENGRK YSRYGRCTGH SSYITHLDWS PDNKYIMSNS GDYEILYWDI PNGCKLIRNR SDCKDIDWTT YTCVLGFQVF GVWPEGSDGT DINALVRSHN RKVIAVADDF CKVHLFQYPC SKAKAPSHKY SAHSSHVTNV SFTHNDSHLI STGGKDMSII QWKLVEKLSL PQNETVADTT LTKAPVSSTE SVIQSNTPTP PPSQPLNETA EEESRISSSP TLLENSLEQT VEPSEDHSEE ESEEGSGDLG EPLYEEPCNE ISKEQAKATL LEDQQDPSPS S
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