rRNA methyltransferase 3, mitochondrial (MRM3)

About rRNA methyltransferase 3, mitochondrial

rRNA methyltransferase 3, mitochondrial (MRM3) is a protein from Homo sapiens identified by UniProt accession Q9HC36, 420 residues long. MolForge cross-references it against 0 known binders and 19 disease associations.

Target properties

Protein name	rRNA methyltransferase 3, mitochondrial
UniProt accession	Q9HC36
Gene	MRM3
Organism	Homo sapiens
Length	420 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (19)

Diseases linked to this target (Open Targets).

refractive error measurement · score 0.07
platelet count · score 0.06
lymphocyte count · score 0.06
heel bone mineral density · score 0.05
platelet component distribution width · score 0.05
platelet crit · score 0.04
exercise-induced hyperinsulinism · score 0.03
Glycogen storage disease due to hepatic glycogen synthase deficiency · score 0.03
glycogen storage disorder due to hepatic glycogen synthase deficiency · score 0.03
colorectal cancer · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9HC36-F1	alphafold	PREDICTED	75.01	—

Amino-acid sequence (420 residues)

MAALVRPARF VVRPLLQVVQ AWDLDARRWV RALRRSPVKV VFPSGEVVEQ KRAPGKQPRK APSEASAQEQ REKQPLEESA SRAPSTWEES GLRYDKAYPG DRRLSSVMTI VKSRPFREKQ GKILLEGRRL ISDALKAGAV PKMFFFSRLE YLKELPVDKL KGVSLIKVKF EDIKDWSDLV TPQGIMGIFA KPDHVKMTYP KTQLQHSLPL LLICDNLRDP GNLGTILRSA AGAGCSKVLL TKGCVDAWEP KVLRAGMGAH FRMPIINNLE WETVPNYLPP DTRVYVADNC GLYAQAEMSN KASDHGWVCD QRVMKFHKYE EEEDVETGAS QDWLPHVEVQ SYDSDWTEAP AAVVIGGETY GVSLESLQLA ESTGGKRLLI PVVPGVDSLN SAMAASILLF EGKRQLRGRA EDLSRDRSYH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards