Vasculin-like protein 1 (GPBP1L1)

About Vasculin-like protein 1

Vasculin-like protein 1 (GPBP1L1) is a protein from Homo sapiens identified by UniProt accession Q9HC44, 474 residues long. MolForge cross-references it against 0 known binders and 38 disease associations.

Target properties

Protein name	Vasculin-like protein 1
UniProt accession	Q9HC44
Gene	GPBP1L1
Organism	Homo sapiens
Length	474 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (38)

Diseases linked to this target (Open Targets).

body mass index · score 0.13
spinal stenosis · score 0.11
age-related hearing impairment · score 0.11
brain measurement · score 0.10
body fat percentage · score 0.10
platelet count · score 0.10
body height · score 0.10
apolipoprotein A 1 measurement · score 0.09
cortical surface area measurement · score 0.09
serum gamma-glutamyl transferase measurement · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9HC44-F1	alphafold	PREDICTED	54.40	—

Amino-acid sequence (474 residues)

MAQHDFVPAW LNFSTPQSAK SPTATFEKHG EHLPRGEGRF GVSRRRHNSS DGFFNNGPLR TAGDSWHQPS LFRHDSVDSG VSKGAYAGIT GNPSGWHSSS RGHDGMSQRS GGGTGNHRHW NGSFHSRKGC AFQEKPPMEI REEKKEDKVE KLQFEEEDFP SLNPEAGKQH QPCRPIGTPS GVWENPPSAK QPSKMLVIKK VSKEDPAAAF SAAFTSPGSH HANGNKLSSV VPSVYKNLVP KPVPPPSKPN AWKANRMEHK SGSLSSSRES AFTSPISVTK PVVLASGAAL SSPKESPSST TPPIEISSSR LTKLTRRTTD RKSEFLKTLK DDRNGDFSEN RDCDKLEDLE DNSTPEPKEN GEEGCHQNGL ALPVVEEGEV LSHSLEAEHR LLKAMGWQEY PENDENCLPL TEDELKEFHM KTEQLRRNGF GKNGFLQSRS SSLFSPWRST CKAEFEDSDT ETSSSETSDD DAWK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards