Chromobox protein homolog 8 (CBX8)

About Chromobox protein homolog 8

Chromobox protein homolog 8 (CBX8) is a protein from Homo sapiens identified by UniProt accession Q9HC52, 389 residues long. MolForge cross-references it against 0 known binders and 108 disease associations.

Target properties

Protein name	Chromobox protein homolog 8
UniProt accession	Q9HC52
Gene	CBX8
Organism	Homo sapiens
Length	389 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (108)

Diseases linked to this target (Open Targets).

lean body mass · score 0.39
monocyte count · score 0.36
platelet count · score 0.35
smoking status measurement · score 0.33
cortical thickness · score 0.33
breast carcinoma · score 0.33
fat body mass · score 0.33
testosterone measurement · score 0.33
risk-taking behaviour · score 0.32
sex hormone-binding globulin measurement · score 0.32

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9HC52-F1	alphafold	PREDICTED	61.74	—

Amino-acid sequence (389 residues)

MELSAVGERV FAAEALLKRR IRKGRMEYLV KWKGWSQKYS TWEPEENILD ARLLAAFEER EREMELYGPK KRGPKPKTFL LKAQAKAKAK TYEFRSDSAR GIRIPYPGRS PQDLASTSRA REGLRNMGLS PPASSTSTSS TCRAEAPRDR DRDRDRDRER DRERERERER ERERERERER GTSRVDDKPS SPGDSSKKRG PKPRKELPDP SQRPLGEPSA GLGEYLKGRK LDDTPSGAGK FPAGHSVIQL ARRQDSDLVQ CGVTSPSSAE ATGKLAVDTF PARVIKHRAA FLEAKGQGAL DPNGTRVRHG SGPPSSGGGL YRDMGAQGGR PSLIARIPVA RILGDPEEES WSPSLTNLEK VVVTDVTSNF LTVTIKESNT DQGFFKEKR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards