About Sodium/potassium/calcium exchanger 3
Sodium/potassium/calcium exchanger 3 (SLC24A3) is a protein
from Homo sapiens identified by UniProt accession
Q9HC58, 644 residues long.
MolForge cross-references it against 0 known binders and
186 disease associations.
Target properties
| Protein name | Sodium/potassium/calcium exchanger 3 |
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| UniProt accession | Q9HC58 |
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| Gene | SLC24A3 |
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| Organism | Homo sapiens |
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| Length | 644 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (186)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.46
- pulse pressure measurement · score 0.46
- migraine disorder · score 0.46
- cataract · score 0.46
- BMI-adjusted hip circumference · score 0.42
- platelet count · score 0.41
- diastolic blood pressure · score 0.38
- FEV/FVC ratio · score 0.37
- systolic blood pressure · score 0.31
- neuritic plaque measurement · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9HC58-F1 | alphafold | PREDICTED | 70.32 | — |
Amino-acid sequence (644 residues)
MRPSGDEDRA RRRRRRRRRR DLLLSQLCFL ASVALLLWSL SSLREQKELD LMDLVGEDRK WMMARKLMQV NDTLTSEDAG LRNSKNCTEP ALHEFPNDIF TNEDRRQGAV VLHVLCAIYM FYALAIVCDD FFVPSLEKIC ERLHLSEDVA GATFMAAGSS APELFTSVIG VFITKGDVGV GTIVGSAVFN ILCIIGVCGL FAGQVVALSS WCLLRDSIYY TLSVIALIVF IYDEKVSWWE SLVLVLMYLI YIVIMKYNAC IHQCFERRTK GAGNMVNGLA NNAEIDDSSN CDATVVLLKK ANFHRKASVI MVDELLSAYP HQLSFSEAGL RIMITSHFPP KTRLSMASRM LINERQRLIN SRAYTNGESE VAIKIPIKHT VENGTGPSSA PDRGVNGTRR DDVVAEAGNE TENENEDNEN DEEEEEDEDD DEGPYTPFDT PSGKLETVKW AFTWPLSFVL YFTVPNCNKP RWEKWFMVTF ASSTLWIAAF SYMMVWMVTI IGYTLGIPDV IMGITFLAAG TSVPDCMASL IVARQGMGDM AVSNSIGSNV FDILIGLGLP WALQTLAVDY GSYIRLNSRG LIYSVGLLLA SVFVTVFGVH LNKWQLDKKL GCGCLLLYGV FLCFSIMTEF NVFTFVNLPM CGDH
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