About Sentrin-specific protease 2
Sentrin-specific protease 2 (SENP2) is a protein
from Homo sapiens identified by UniProt accession
Q9HC62, 589 residues long.
MolForge cross-references it against 0 known binders and
104 disease associations.
Target properties
| Protein name | Sentrin-specific protease 2 |
|---|
| UniProt accession | Q9HC62 |
|---|
| Gene | SENP2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 589 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (104)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- lysosomal storage disease · score 0.33
- diastolic blood pressure · score 0.31
- urate measurement · score 0.29
- glomerular filtration rate · score 0.28
- systolic blood pressure · score 0.27
- neutrophil count · score 0.27
- QRS duration · score 0.24
- sex hormone-binding globulin measurement · score 0.24
- PR interval · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9HC62-F1 | alphafold | PREDICTED | 62.06 | — |
Amino-acid sequence (589 residues)
MYRWLVRILG TIFRFCDRSV PPARALLKRR RSDSTLFSTV DTDEIPAKRP RLDCFIHQVK NSLYNAASLF GFPFQLTTKP MVTSACNGTR NVAPSGEVFS NSSSCELTGS GSWNNMLKLG NKSPNGISDY PKIRVTVTRD QPRRVLPSFG FTLNSEGCNR RPGGRRHSKG NPESSLMWKP QEQAVTEMIS EESGKGLRRP HCTVEEGVQK EEREKYRKLL ERLKESGHGN SVCPVTSNYH SSQRSQMDTL KTKGWGEEQN HGVKTTQFVP KQYRLVETRG PLCSLRSEKR CSKGKITDTE TMVGIRFENE SRRGYQLEPD LSEEVSARLR LGSGSNGLLR RKVSIIETKE KNCSGKERDR RTDDLLELTE DMEKEISNAL GHGPQDEILS SAFKLRITRG DIQTLKNYHW LNDEVINFYM NLLVERNKKQ GYPALHVFST FFYPKLKSGG YQAVKRWTKG VNLFEQEIIL VPIHRKVHWS LVVIDLRKKC LKYLDSMGQK GHRICEILLQ YLQDESKTKR NSDLNLLEWT HHSMKPHEIP QQLNGSDCGM FTCKYADYIS RDKPITFTQH QMPLFRKKMV WEILHQQLL
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