Cytokine receptor-like factor 2 (CRLF2)

About Cytokine receptor-like factor 2

Cytokine receptor-like factor 2 (CRLF2) is a protein from Homo sapiens identified by UniProt accession Q9HC73, 371 residues long. MolForge cross-references it against 0 known binders and 250 disease associations.

Target properties

Protein name	Cytokine receptor-like factor 2
UniProt accession	Q9HC73
Gene	CRLF2
Organism	Homo sapiens
Length	371 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (250)

Diseases linked to this target (Open Targets).

cutaneous melanoma · score 0.37
superficial spreading melanoma · score 0.37
hemangioblastoma · score 0.37
skin basal cell carcinoma · score 0.37
lung carcinoma · score 0.37
Merkel cell skin cancer · score 0.37
acute lymphoblastic leukemia · score 0.34
melanoma · score 0.28
B-cell acute lymphoblastic leukemia · score 0.28
colorectal adenocarcinoma · score 0.28

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9HC73-F1	alphafold	PREDICTED	77.24	—

Amino-acid sequence (371 residues)

MGRLVLLWGA AVFLLGGWMA LGQGGAAEGV QIQIIYFNLE TVQVTWNASK YSRTNLTFHY RFNGDEAYDQ CTNYLLQEGH TSGCLLDAEQ RDDILYFSIR NGTHPVFTAS RWMVYYLKPS SPKHVRFSWH QDAVTVTCSD LSYGDLLYEV QYRSPFDTEW QSKQENTCNV TIEGLDAEKC YSFWVRVKAM EDVYGPDTYP SDWSEVTCWQ RGEIRDACAE TPTPPKPKLS KFILISSLAI LLMVSLLLLS LWKLWRVKKF LIPSVPDPKS IFPGLFEIHQ GNFQEWITDT QNVAHLHKMA GAEQESGPEE PLVVQLAKTE AESPRMLDPQ TEEKEASGGS LQLPHQPLQG GDVVTIGGFT FVMNDRSYVA L

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards