About Zinc finger and BTB domain-containing protein 20
Zinc finger and BTB domain-containing protein 20 (ZBTB20) is a protein
from Homo sapiens identified by UniProt accession
Q9HC78, 741 residues long.
MolForge cross-references it against 0 known binders and
239 disease associations.
Target properties
| Protein name | Zinc finger and BTB domain-containing protein 20 |
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| UniProt accession | Q9HC78 |
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| Gene | ZBTB20 |
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| Organism | Homo sapiens |
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| Length | 741 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (239)
Diseases linked to this target (Open Targets).
- Primrose syndrome · score 0.80
- Intellectual disability - cataracts - calcified pinnae - myopathy · score 0.54
- genetic disorder · score 0.52
- Intellectual disability · score 0.49
- body height · score 0.38
- platelet count · score 0.38
- diabetes mellitus · score 0.37
- alkaline phosphatase measurement · score 0.37
- hematocrit · score 0.37
- body mass index · score 0.36
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9HC78-F1 | alphafold | PREDICTED | 52.19 | — |
Amino-acid sequence (741 residues)
MLERKKPKTA ENQKASEENE ITQPGGSSAK PGLPCLNFEA VLSPDPALIH STHSLTNSHA HTGSSDCDIS CKGMTERIHS INLHNFSNSV LETLNEQRNR GHFCDVTVRI HGSMLRAHRC VLAAGSPFFQ DKLLLGYSDI EIPSVVSVQS VQKLIDFMYS GVLRVSQSEA LQILTAASIL QIKTVIDECT RIVSQNVGDV FPGIQDSGQD TPRGTPESGT SGQSSDTESG YLQSHPQHSV DRIYSALYAC SMQNGSGERS FYSGAVVSHH ETALGLPRDH HMEDPSWITR IHERSQQMER YLSTTPETTH CRKQPRPVRI QTLVGNIHIK QEMEDDYDYY GQQRVQILER NESEECTEDT DQAEGTESEP KGESFDSGVS SSIGTEPDSV EQQFGPGAAR DSQAEPTQPE QAAEAPAEGG PQTNQLETGA SSPERSNEVE MDSTVITVSN SSDKSVLQQP SVNTSIGQPL PSTQLYLRQT ETLTSNLRMP LTLTSNTQVI GTAGNTYLPA LFTTQPAGSG PKPFLFSLPQ PLAGQQTQFV TVSQPGLSTF TAQLPAPQPL ASSAGHSTAS GQGEKKPYEC TLCNKTFTAK QNYVKHMFVH TGEKPHQCSI CWRSFSLKDY LIKHMVTHTG VRAYQCSICN KRFTQKSSLN VHMRLHRGEK SYECYICKKK FSHKTLLERH VALHSASNGT PPAGTPPGAR AGPPGVVACT EGTTYVCSVC PAKFDQIEQF NDHMRMHVSD G
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