About E3 SUMO-protein ligase KIAA1586
E3 SUMO-protein ligase KIAA1586 (KIAA1586) is a protein
from Homo sapiens identified by UniProt accession
Q9HCI6, 787 residues long.
MolForge cross-references it against 0 known binders and
8 disease associations.
Target properties
| Protein name | E3 SUMO-protein ligase KIAA1586 |
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| UniProt accession | Q9HCI6 |
|---|
| Gene | KIAA1586 |
|---|
| Organism | Homo sapiens |
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| Length | 787 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (8)
Diseases linked to this target (Open Targets).
- leukocyte count · score 0.20
- lymphocyte count · score 0.20
- neurodegenerative disease · score 0.16
- body height · score 0.06
- mean corpuscular volume · score 0.02
- body mass index · score 0.02
- cystic fibrosis · score 0.00
- Autism · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9HCI6-F1 | alphafold | PREDICTED | 73.93 | — |
Amino-acid sequence (787 residues)
MGDPGSEIIE SVPPAGPEAS ESTTDENEDD IQFVSEGPSR PVLEYIDLVC GDDENPSAYY SDILFPKMPK RQGDFLHFLN VKKVKTDTEN NEVSKNHCRL SKAKEPHFEY IEQPIIEEKP SLSSKKEIDN LVLPDCWNEK QAFMFTEQYK WLEIKEGKLG CKDCSAVRHL GSKAEKHVHV SKEWIAYLVT PNGSNKTTRQ ASLRKKIREH DVSKAHGKIQ DLLKESTNDS ICNLVHKQNN KNIDATVKVF NTVYSLVKHN RPLSDIEGAR ELQEKNGEVN CLNTRYSATR IAEHIAKEMK MKIFKNIIEE NAKICIIIDE ASTVSKKTTL VIYLQCTIQS APAPVMLFVA LKELVSTIAE CIVNTLLTTL NDCGFTNEYL KANLIAFCSD GANTILGRKS GVATKLLENF PEIIIWNCLN HRLQLSLDDS ISEIKQINHL KIFIDKIYSI YHQPNKNQTK LLGTVAKELE TEIIKIGRVM GPRWAACSLQ AATAVWHAYP ILYMHFSHSY SGLAKRLANI NFLQDLALMI DILEEFSVLS TALQSRSTNI KKAQKLIKRT IRALENLKIG TGKYESQIED LIKSDKFKDI PFNKNNKFNA LPRSILLDNI IQHMNLRLLS DRNHEDIFNY FDLLEPSTWP YEEITSPWIA GEKTLFHLCK ILKYEVDLND FREFVNNNIK SNNVSIPTTI YKAKKIVSTI AINSAEAERG FNLMNIICTR VRNSLTIDHV SDLMTINLLG KELADWDATP FVKSWSNCNH RLATDTRVRQ KSTKVFHENQ LAIWNLK
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