About E3 ubiquitin-protein ligase MSL2
E3 ubiquitin-protein ligase MSL2 (MSL2) is a protein
from Homo sapiens identified by UniProt accession
Q9HCI7, 577 residues long.
MolForge cross-references it against 0 known binders and
106 disease associations.
Target properties
| Protein name | E3 ubiquitin-protein ligase MSL2 |
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| UniProt accession | Q9HCI7 |
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| Gene | MSL2 |
|---|
| Organism | Homo sapiens |
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| Length | 577 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (106)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- body height · score 0.28
- sex hormone-binding globulin measurement · score 0.28
- alkaline phosphatase measurement · score 0.27
- testosterone measurement · score 0.26
- serum alanine aminotransferase measurement · score 0.26
- schizophrenia · score 0.26
- bilirubin measurement · score 0.26
- calcium measurement · score 0.25
- blood urea nitrogen measurement · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9HCI7-F1 | alphafold | PREDICTED | 55.87 | — |
Amino-acid sequence (577 residues)
MNPVNATALY ISASRLVLNY DPGDPKAFTE INRLLPYFRQ SLSCCVCGHL LQDPIAPTNS TCQHYVCKTC KGKKMMMKPS CSWCKDYEQF EENKQLSILV NCYKKLCEYI TQTTLARDII EAVDCSSDIL ALLNDGSLFC EETEKPSDSS FTLCLTHSPL PSTSEPTTDP QASLSPMSES TLSIAIGSSV INGLPTYNGL SIDRFGINIP SPEHSNTIDV CNTVDIKTED LSDSLPPVCD TVATDLCSTG IDICSFSEDI KPGDSLLLSV EEVLRSLETV SNTEVCCPNL QPNLEATVSN GPFLQLSSQS LSHNVFMSTS PALHGLSCTA ATPKIAKLNR KRSRSESDSE KVQPLPISTI IRGPTLGASA PVTVKRESKI SLQPIATVPN GGTTPKISKT VLLSTKSMKK SHEHGSKKSH SKTKPGILKK DKAVKEKIPS HHFMPGSPTK TVYKKPQEKK GCKCGRATQN PSVLTCRGQR CPCYSNRKAC LDCICRGCQN SYMANGEKKL EAFAVPEKAL EQTRLTLGIN VTSIAVRNAS TSTSVINVTG SPVTTFLAAS THDDKSLDEA IDMRFDC
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