About Trinucleotide repeat-containing gene 6C protein
Trinucleotide repeat-containing gene 6C protein (TNRC6C) is a protein
from Homo sapiens identified by UniProt accession
Q9HCJ0, 1936 residues long.
MolForge cross-references it against 0 known binders and
75 disease associations.
Target properties
| Protein name | Trinucleotide repeat-containing gene 6C protein |
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| UniProt accession | Q9HCJ0 |
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| Gene | TNRC6C |
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| Organism | Homo sapiens |
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| Length | 1936 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (75)
Diseases linked to this target (Open Targets).
- cancer · score 0.46
- mathematical ability · score 0.37
- erythrocyte count · score 0.35
- self reported educational attainment · score 0.33
- glioblastoma multiforme · score 0.29
- ovarian cancer · score 0.29
- breast adenocarcinoma · score 0.29
- body mass index · score 0.28
- endometrial cancer · score 0.28
- head and neck squamous cell carcinoma · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9HCJ0-F1 | alphafold | PREDICTED | 40.33 | — |
Amino-acid sequence (1936 residues)
MEEKKKKKQE EKKKKEGAQK KAADQKTKVP EPTKTCSSQP QPAGTSTSTS TSTISSSNNG KRASASGQQP AASRYLPREV PPRFRQQEQK QLLKRGQPLP TGTLTSVSPT QGAGPAGVSP PPLPGAGTQH HPSKLQPDLS HSGLADHYEN SHWGQQPTYR SEANCSWDKV IIDRTDKEAW PSITGTETES ASECTTDTDS ASNCGSENSS MATGSAQGNF TGHTKKTNGN NGTNGALVQS PSNQSALGAG GANSNGSAAR VWGVATGSSS GLAHCSVSGG DGKMDTMIGD GRSQNCWGAS NSNAGINLNL NPNANPAAWP VLGHEGTVAT GNPSSICSPV SAIGQNMGNQ NGNPTGTLGA WGNLLPQEST EPQTSTSQNV SFSAQPQNLN TDGPNNTNPM NSSPNPINAM QTNGLPNWGM AVGMGAIIPP HLQGLPGANG SSVSQVSGGS AEGISNSVWG LSPGNPATGN SNSGFSQGNG DTVNSALSAK QNGSSSAVQK EGSGGNAWDS GPPAGPGILA WGRGSGNNGV GNIHSGAWGH PSRSTSNGVN GEWGKPPNQH SNSDINGKGS TGWESPSVTS QNPTVQPGGE HMNSWAKAAS SGTTASEGSS DGSGNHNEGS TGREGTGEGR RRDKGIIDQG HIQLPRNDLD PRVLSNTGWG QTPVKQNTAW EFEESPRSER KNDNGTEAWG CAATQASNSG GKNDGSIMNS TNTSSVSGWV NAPPAAVPAN TGWGDSNNKA PSGPGVWGDS ISSTAVSTAA AAKSGHAWSG AANQEDKSPT WGEPPKPKSQ HWGDGQRSNP AWSAGGGDWA DSSSVLGHLG DGKKNGSGWD ADSNRSGSGW NDTTRSGNSG WGNSTNTKAN PGTNWGETLK PGPQQNWASK PQDNNVSNWG GAASVKQTGT GWIGGPVPVK QKDSSEATGW EEPSPPSIRR KMEIDDGTSA WGDPSNYNNK TVNMWDRNNP VIQSSTTTNT TTTTTTTTSN TTHRVETPPP HQAGTQLNRS PLLGPVSSGW GEMPNVHSKT ENSWGEPSSP STLVDNGTAA WGKPPSSGSG WGDHPAEPPV AFGRAGAPVA ASALCKPASK SMQEGWGSGG DEMNLSTSQW EDEEGDVWNN AASQESTSSC SSWGNAPKKG LQKGMKTSGK QDEAWIMSRL IKQLTDMGFP REPAEEALKS NNMNLDQAMS ALLEKKVDVD KRGLGVTDHN GMAAKPLGCR PPISKESSVD RPTFLDKDGG LVEEPTPSPF LPSPSLKLPL SHSALPSQAL GGIASGLGMQ NLNSSRQIPS GNLGMFGNSG AAQARTMQQP PQPPVQPLNS SQPSLRAQVP QFLSPQVQAQ LLQFAAKNIG LNPALLTSPI NPQHMTMLNQ LYQLQLAYQR LQIQQQMLQA QRNVSGSMRQ QEQQVARTIT NLQQQIQQHQ RQLAQALLVK QPPPPPPPPH LSLHPSAGKS AMDSFPSHPQ TPGLPDLQTK EQQSSPNTFA PYPLAGLNPN MNVNSMDMTG GLSVKDPSQS QSRLPQWTHP NSMDNLPSAA SPLEQNPSKH GAIPGGLSIG PPGKSSIDDS YGRYDLIQNS ESPASPPVAV PHSWSRAKSD SDKISNGSSI NWPPEFHPGV PWKGLQNIDP ENDPDVTPGS VPTGPTINTT IQDVNRYLLK SGGSSPPSSQ NATLPSSSAW PLSASGYSSS FSSIASAPSV AGKLSDIKST WSSGPTSHTQ ASLSHELWKV PRNSTAPTRP PPGLTNPKPS STWGASPLGW TSSYSSGSAW STDTSGRTSS WLVLRNLTPQ IDGSTLRTLC LQHGPLITFH LNLTQGNAVV RYSSKEEAAK AQKSLHMCVL GNTTILAEFA GEEEVNRFLA QGQALPPTSS WQSSSASSQP RLSAAGSSHG LVRSDAGHWN APCLGGKGSS ELLWGGVPQY SSSLWGPPSA DDSRVIGSPT PLTTLLPGDL LSGESL
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