Mineralization regulator ANKH (ANKH)

About Mineralization regulator ANKH

Mineralization regulator ANKH (ANKH) is a protein from Homo sapiens identified by UniProt accession Q9HCJ1, 492 residues long. MolForge cross-references it against 0 known binders and 238 disease associations.

Target properties

Protein name	Mineralization regulator ANKH
UniProt accession	Q9HCJ1
Gene	ANKH
Organism	Homo sapiens
Length	492 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (238)

Diseases linked to this target (Open Targets).

chondrocalcinosis 2 · score 0.79
craniometaphyseal dysplasia · score 0.69
HbA1c measurement · score 0.57
type 2 diabetes mellitus · score 0.49
glaucoma · score 0.46
intraocular pressure measurement · score 0.45
diabetes mellitus · score 0.44
blood phosphate measurement · score 0.44
open-angle glaucoma · score 0.40
blood metabolite measurement · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9HCJ1-F1	alphafold	PREDICTED	84.46	—

Amino-acid sequence (492 residues)

MVKFPALTHY WPLIRFLVPL GITNIAIDFG EQALNRGIAA VKEDAVEMLA SYGLAYSLMK FFTGPMSDFK NVGLVFVNSK RDRTKAVLCM VVAGAIAAVF HTLIAYSDLG YYIINKLHHV DESVGSKTRR AFLYLAAFPF MDAMAWTHAG ILLKHKYSFL VGCASISDVI AQVVFVAILL HSHLECREPL LIPILSLYMG ALVRCTTLCL GYYKNIHDII PDRSGPELGG DATIRKMLSF WWPLALILAT QRISRPIVNL FVSRDLGGSS AATEAVAILT ATYPVGHMPY GWLTEIRAVY PAFDKNNPSN KLVSTSNTVT AAHIKKFTFV CMALSLTLCF VMFWTPNVSE KILIDIIGVD FAFAELCVVP LRIFSFFPVP VTVRAHLTGW LMTLKKTFVL APSSVLRIIV LIASLVVLPY LGVHGATLGV GSLLAGFVGE STMVAIAACY VYRKQKKKME NESATEGEDS AMTDMPPTEE VTDIVEMREE NE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards