About Leucine-rich repeat-containing protein 4C
Leucine-rich repeat-containing protein 4C (LRRC4C) is a protein
from Homo sapiens identified by UniProt accession
Q9HCJ2, 640 residues long.
MolForge cross-references it against 0 known binders and
63 disease associations.
Target properties
| Protein name | Leucine-rich repeat-containing protein 4C |
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| UniProt accession | Q9HCJ2 |
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| Gene | LRRC4C |
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| Organism | Homo sapiens |
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| Length | 640 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (63)
Diseases linked to this target (Open Targets).
- smoking status measurement · score 0.46
- self reported educational attainment · score 0.45
- Myopia · score 0.44
- refractive error · score 0.44
- mathematical ability · score 0.42
- risk-taking behaviour · score 0.40
- attention deficit hyperactivity disorder · score 0.38
- antisocial behaviour measurement · score 0.38
- substance abuse · score 0.38
- protein measurement · score 0.38
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9HCJ2-F1 | alphafold | PREDICTED | 75.83 | — |
Amino-acid sequence (640 residues)
MLNKMTLHPQ QIMIGPRFNR ALFDPLLVVL LALQLLVVAG LVRAQTCPSV CSCSNQFSKV ICVRKNLREV PDGISTNTRL LNLHENQIQI IKVNSFKHLR HLEILQLSRN HIRTIEIGAF NGLANLNTLE LFDNRLTTIP NGAFVYLSKL KELWLRNNPI ESIPSYAFNR IPSLRRLDLG ELKRLSYISE GAFEGLSNLR YLNLAMCNLR EIPNLTPLIK LDELDLSGNH LSAIRPGSFQ GLMHLQKLWM IQSQIQVIER NAFDNLQSLV EINLAHNNLT LLPHDLFTPL HHLERIHLHH NPWNCNCDIL WLSWWIKDMA PSNTACCARC NTPPNLKGRY IGELDQNYFT CYAPVIVEPP ADLNVTEGMA AELKCRASTS LTSVSWITPN GTVMTHGAYK VRIAVLSDGT LNFTNVTVQD TGMYTCMVSN SVGNTTASAT LNVTAATTTP FSYFSTVTVE TMEPSQDEAR TTDNNVGPTP VVDWETTNVT TSLTPQSTRS TEKTFTIPVT DINSGIPGID EVMKTTKIII GCFVAITLMA AVMLVIFYKM RKQHHRQNHH APTRTVEIIN VDDEITGDTP MESHLPMPAI EHEHLNHYNS YKSPFNHTTT VNTINSIHSS VHEPLLIRMN SKDNVQETQI
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