About Ribonucleoprotein PTB-binding 2
Ribonucleoprotein PTB-binding 2 (RAVER2) is a protein
from Homo sapiens identified by UniProt accession
Q9HCJ3, 691 residues long.
MolForge cross-references it against 0 known binders and
52 disease associations.
Target properties
| Protein name | Ribonucleoprotein PTB-binding 2 |
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| UniProt accession | Q9HCJ3 |
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| Gene | RAVER2 |
|---|
| Organism | Homo sapiens |
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| Length | 691 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (52)
Diseases linked to this target (Open Targets).
- eosinophil count · score 0.44
- lean body mass · score 0.42
- fat body mass · score 0.37
- central nervous system cancer · score 0.37
- C-reactive protein measurement · score 0.35
- appendicular lean mass · score 0.35
- body height · score 0.34
- serum albumin measurement · score 0.30
- eosinophil percentage of leukocytes · score 0.30
- whole body water mass · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9HCJ3-F1 | alphafold | PREDICTED | 60.98 | — |
Amino-acid sequence (691 residues)
MAAAAGDGGG EGGAGLGSAA GLGPGPGLRG QGPSAEAHEG APDPMPAALH PEEVAARLQR MQRELSNRRK ILVKNLPQDS NCQEVHDLLK DYDLKYCYVD RNKRTAFVTL LNGEQAQNAI QMFHQYSFRG KDLIVQLQPT DALLCITNVP ISFTSEEFEE LVRAYGNIER CFLVYSEVTG HSKGYGFVEY MKKDFAAKAR LELLGRQLGA SALFAQWMDV NLLASELIHS KCLCIDKLPS DYRDSEELLQ IFSSVHKPVF CQLAQDEGSY VGGFAVVEYS TAEQAEEVQQ AADGMTIKGS KVQVSFCAPG APGRSTLAAL IAAQRVMHSN QKGLLPEPNP VQIMKSLNNP AMLQVLLQPQ LCGRAVKPAV LGTPHSLPHL MNPSISPAFL HLNKAHQSSV MGNTSNLFLQ NLSHIPLAQQ QLMKFENIHT NNKPGLLGEP PAVVLQTALG IGSVLPLKKE LGHHHGEAHK TSSLIPTQTT ITAGMGMLPF FPNQHIAGQA GPGHSNTQEK QPATVGMAEG NFSGSQPYLQ SFPNLAAGSL LVGHHKQQQS QPKGTEISSG AASKNQTSLL GEPPKEIRLS KNPYLNLASV LPSVCLSSPA SKTTLHKTGI ASSILDAISQ GSESQHALEK CIAYSPPFGD YAQVSSLRNE KRGSSYLISA PEGGSVECVD QHSQGTGAYY METYLKKKRV Y
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