About Zinc finger SWIM domain-containing protein 6
Zinc finger SWIM domain-containing protein 6 (ZSWIM6) is a protein
from Homo sapiens identified by UniProt accession
Q9HCJ5, 1215 residues long.
MolForge cross-references it against 0 known binders and
112 disease associations.
Target properties
| Protein name | Zinc finger SWIM domain-containing protein 6 |
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| UniProt accession | Q9HCJ5 |
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| Gene | ZSWIM6 |
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| Organism | Homo sapiens |
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| Length | 1215 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (112)
Diseases linked to this target (Open Targets).
- acromelic frontonasal dysostosis · score 0.76
- neurodevelopmental disorder with movement abnormalities, abnormal gait, and autistic features · score 0.63
- schizophrenia · score 0.50
- platelet count · score 0.50
- self reported educational attainment · score 0.49
- lean body mass · score 0.48
- mathematical ability · score 0.47
- Acromelic frontonasal dysplasia · score 0.46
- body mass index · score 0.45
- appendicular lean mass · score 0.43
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9HCJ5-F1 | alphafold | PREDICTED | 77.86 | — |
Amino-acid sequence (1215 residues)
MAERGQQPPP AKRLCCRPGG GGGGGGSSGG GGGAGGGYSS ACRPGPRAGG AAAAAACGGG AALGLLPPGK TQSPESLLDI AARRVAEKWP FQRVEERFER IPEPVQRRIV YWSFPRSERE ICMYSSFNTG GGAAGGPGDD SGGGGGAGGG GGGGSSSSPA ATSAAATSAA AAAAAAAAAA AAAAGAGAPS VGAAGAADGG DETRLPFRRG IALLESGCVD NVLQVGFHLS GTVTEPAIQS EPETVCNVAI SFDRCKITSV TCSCGNKDIF YCAHVVALSL YRIRKPDQVK LHLPISETLF QMNRDQLQKF VQYLITVHHT EVLPTAQKLA DEILSQNSEI NQVHGAPDPT AGASIDDENC WHLDEEQVQE QVKLFLSQGG YHGSGKQLNL LFAKVREMLK MRDSNGARML TLITEQFMAD PRLSLWRQQG TAMTDKYRQL WDELGALWMC IVLNPHCKLE QKASWLKQLK KWNSVDVCPW EDGNHGSELP NLTNALPQGA NANQDSSNRP HRTVFTRAIE ACDLHWQDSH LQHIISSDLY TNYCYHDDTE NSLFDSRGWP LWHEHVPTAC ARVDALRSHG YPREALRLAI AIVNTLRRQQ QKQLEMFRTQ KKELPHKNIT SITNLEGWVG HPLDPVGTLF SSLMEACRID DENLSGFSDF TENMGQCKSL EYQHLPAHKF LEEGESYLTL AVEVALIGLG QQRIMPDGLY TQEKVCRNEE QLISKLQEIE LDDTLVKIFR KQAVFLLEAG PYSGLGEIIH RESVPMHTFA KYLFTSLLPH DAELAYKIAL RAMRLLVLES TAPSGDLTRP HHIASVVPNR YPRWFTLSHI ESQQCELAST MLTAAKGDVR RLETVLESIQ KNIHSSSHIF KLAQDAFKIA TLMDSLPDIT LLKVSLELGL QVMRMTLSTL NWRRREMVRW LVTCATEVGV YALDSIMQTW FTLFTPTEAT SIVATTVMSN STIVRLHLDC HQQEKLASSA RTLALQCAMK DPQNCALSAL TLCEKDHIAF ETAYQIVLDA ATTGMSYTQL FTIARYMEHR GYPMRAYKLA TLAMTHLNLS YNQDTHPAIN DVLWACALSH SLGKNELAAI IPLVVKSVKC ATVLSDILRR CTLTTPGMVG LHGRRNSGKL MSLDKAPLRQ LLDATIGAYI NTTHSRLTHI SPRHYSEFIE FLSKARETFL MAHDGHIQFT QFIDNLKQIY KGKKKLMMLV RERFG
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