About Putative NADPH-dependent quinone oxidoreductase VAT1L
Putative NADPH-dependent quinone oxidoreductase VAT1L (VAT1L) is a protein
from Homo sapiens identified by UniProt accession
Q9HCJ6, 419 residues long.
MolForge cross-references it against 0 known binders and
34 disease associations.
Target properties
| Protein name | Putative NADPH-dependent quinone oxidoreductase VAT1L |
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| UniProt accession | Q9HCJ6 |
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| Gene | VAT1L |
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| Organism | Homo sapiens |
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| Length | 419 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (34)
Diseases linked to this target (Open Targets).
- refractive error measurement · score 0.44
- allergic rhinitis · score 0.24
- sleep duration · score 0.23
- low density lipoprotein cholesterol measurement · score 0.23
- Rectal prolapse · score 0.12
- undetermined early-onset epileptic encephalopathy · score 0.12
- developmental and epileptic encephalopathy · score 0.12
- developmental and epileptic encephalopathy, 28 · score 0.12
- open-angle glaucoma · score 0.09
- Barrett's esophagus · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9HCJ6-F1 | alphafold | PREDICTED | 86.02 | — |
Amino-acid sequence (419 residues)
MAKEGVEKAE ETEQMIEKEA GKEPAEGGGG DGSHRLGDAQ EMRAVVLAGF GGLNKLRLFR KAMPEPQDGE LKIRVKACGL NFIDLMVRQG NIDNPPKTPL VPGFECSGIV EALGDSVKGY EIGDRVMAFV NYNAWAEVVC TPVEFVYKIP DDMSFSEAAA FPMNFVTAYV MLFEVANLRE GMSVLVHSAG GGVGQAVAQL CSTVPNVTVF GTASTFKHEA IKDSVTHLFD RNADYVQEVK RISAEGVDIV LDCLCGDNTG KGLSLLKPLG TYILYGSSNM VTGETKSFFS FAKSWWQVEK VNPIKLYEEN KVIAGFSLLN LLFKQGRAGL IRGVVEKLIG LYNQKKIKPV VDSLWALEEV KEAMQRIHDR GNIGKLILDV EKTPTPLMAN DSTETSEAGE EEEDHEGDSE NKERMPFIQ
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