About Retroelement silencing factor 1
Retroelement silencing factor 1 (RESF1) is a protein
from Homo sapiens identified by UniProt accession
Q9HCM1, 1747 residues long.
MolForge cross-references it against 0 known binders and
104 disease associations.
Target properties
| Protein name | Retroelement silencing factor 1 |
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| UniProt accession | Q9HCM1 |
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| Gene | RESF1 |
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| Organism | Homo sapiens |
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| Length | 1747 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (104)
Diseases linked to this target (Open Targets).
- Red cell distribution width · score 0.46
- eosinophil count · score 0.45
- IGF-1 measurement · score 0.44
- mean reticulocyte volume · score 0.43
- mean corpuscular volume · score 0.39
- eosinophil percentage of leukocytes · score 0.39
- blood phosphate measurement · score 0.30
- Testicular Germ Cell Tumor · score 0.29
- low density lipoprotein cholesterol measurement · score 0.29
- insulin like growth factor measurement · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9HCM1-F1 | alphafold | PREDICTED | 38.22 | — |
Amino-acid sequence (1747 residues)
MNWNEKPKSA TLPPLYPKSQ PPFLHQSLIN QITTTSQSSF SYPGSNQEAC MYPGNSNPIS QPLLNIQNYP QQISVSDMHN GTVVASHTSV ERITYANVNG PKQLTHNLQM SSGVTQNVWL NSPMRNPVHS HIGATVSHQT DFGANVPNMP ALQSQLITSD TYSMQMQMIP SNSTRLPVAY QGNQGLNQSF SEQQVDWTQQ CISKGLTYPD YRPPPKLYRY SPQSFLPDST IQKQNFIPHT SLQVKNSQLL NSVLTLPSRQ TSAVPSQQYA TQTDKRPPPP PYNCRYGSQP LQSTQHITKH LSMEVPQSRE MLSSEIRTSF QQQWQNPNEN VSTIGNFTNL KVNTNSKQPF NSPIRSSVDG VQTLAQTNEE KIMDSCNPTS NQVLDTSVAK EKLVRDIKTL VEIKQKFSEL ARKIKINKDL LMAAGCIKMT NTSYSEPAQN SKLSLKQTAK IQSGPQITPV MPENAERQTP TVVESAETNK TQCMLNSDIQ EVNCRRFNQV DSVLPNPVYS EKRPMPDSSH DVKVLTSKTS AVEMTQAVLN TQLSSENVTK VEQNSPAVCE TISVPKSMST EEYKSKIQNE NMLLLALLSQ ARKTQKTVLK DANQTIQDSK PDSCEMNPNT QMTGNQLNLK NMETPSTSNV SGRVLDNSFC SGQESSTKGM PAKSDSSCSM EVLATCLSLW KKQPSDTAKE KECDKLRTNT TAVGISKPAN IHVKSPCSVV GNSNSQNKIS NPSQQTALSM VMHNYESSGI NITKGTELQI AVVSPLVLSE VKTLSVKGIT PAVLPETVYP VIKEGSVCSL QNQLAENAKA TAALKVDVSG PVASTATSTK IFPLTQKEKQ NESTNGNSEV TPNVNQGKHN KLESAIHSPM NDQQISQESR NSTVVSSDTL QIDNICSLVE GDTSYNSQIA KIFSSLPLKM VEPQKPSLPN QQGIGSREPE KQLDNTTENK DFGFQKDKPV QCTDVSHKIC DQSKSEPPLE SSFNNLETNR VILEKSSLEH ATEKSTANDT CSSAAIQEDI YPQEIDASSN YTPQDPARNE IHSDKAPVLY LHDQLSELLK EFPYGIEAVN TREGSVGQQT TYQTSEDQTA DKTSSDSKDP ADQIQITILS SEQMKEIFPE QDDQPYVVDK LAEPQKEEPI TEVVSQCDLQ APAAGQSRDS VILDSEKDDI HCCALGWLSM VYEGVPQCQC NSIKNSSSEE EKQKEQCSPL DTNSCKQGER TSDRDVTVVQ FKSLVNNPKT PPDGKSHFPE LQDDSRKDTP KTKHKSLPRT EQELVAGQFS SKCDKLNPLQ NHKRKKLRFH EVTFHSSNKM TASYEQASQE TRQKKHVTQN SRPLKTKTAF LPNKDVYKKH SSLGQSLSPE KIKLKLKSVS FKQKRKLDQG NVLDMEVKKK KHDKQEQKGS VGATFKLGDS LSNPNERAIV KEKMVSNTKS VDTKASSSKF SRILTPKEYL QRQKHKEALS NKASKKICVK NVPCDSEHMR PSKLAVQVES CGKSNEKHSS GVQTSKESLN GLTSHGKNLK IHHSQESKTY NILRNVKEKV GGKQPDKIWI DKTKLDKLTN ISNEAQFSQM PPQVKDQKKL YLNRVGFKCT ERESISLTKL ESSPRKLHKD KRQENKHKTF LPVKGNTEKS NMLEFKLCPD ILLKNTNSVE ERKDVKPHPR KEQAPLQVSG IKSTKEDWLK FVATKKRTQK DSQERDNVNS RLSKRSFSAD GFEMLQNPVK DSKEMFQTYK QMYLEKRSRS LGSSPVK
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