Fibrosin-1-like protein (FBRSL1)

About Fibrosin-1-like protein

Fibrosin-1-like protein (FBRSL1) is a protein from Homo sapiens identified by UniProt accession Q9HCM7, 1045 residues long. MolForge cross-references it against 0 known binders and 79 disease associations.

Target properties

Protein name	Fibrosin-1-like protein
UniProt accession	Q9HCM7
Gene	FBRSL1
Organism	Homo sapiens
Length	1045 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (79)

Diseases linked to this target (Open Targets).

Microcephaly · score 0.46
cleft palate · score 0.46
Intellectual disability · score 0.46
Abnormal heart morphology · score 0.46
Hearing impairment · score 0.46
microcephaly · score 0.46
contracture · score 0.46
congenital heart disease · score 0.46
Cleft palate · score 0.46
leukocyte count · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9HCM7-F1	alphafold	PREDICTED	45.57	—

Amino-acid sequence (1045 residues)

MEAKVRPSRR SRAQRDRGRR REAARDARAQ SPSSGDEPEP SPGKENAGLR GAPPRGAAPA PRTARPPRRR RRESSSQEEE VIDGFAIASF STLEALEKDM ALKPHERKEK WERRLIKKPR ESETCPPAEP SENRRPLEAG SPGQDLEPAC DGARKVPLQP SKQMKVTVSK GGDRDSDDDS VLEATSSRDP LSDSSAHAVS GRGYSCDSES GPDDKASVGS EKLFAPGTDK GPALEKSEAK AGPVPKVSGL ERSRELSAES FLPTASPAPH AAPCPGPPPG SRANPLVKKE PPAPHRHTPQ PPPPQPRGLL PTHVPASLGA FAGHSQAAAN GLHGLSRSSS APLGLGKHVS LSPHGPGPHL STSHLALRSQ AQHQLHAAMF AAPPTLPPPP ALPASSLVLP GHPADHELLR QELNTRFLVQ SAERPGASLG PGALLRAEFH QHQHTHQHTH QHTHQHQHTF APFPAGLPPT PPAAPPPFDK YAPKLDSPYF RHSSVSFFPS FPPAIPGLPT LLPHPGPFGS LQGAFQPKVS DPYRAVVKVS TCWEGPWQGR TLVPPGRPRG ARDSRSLQKT WVGVAPAPLS ASILSQKPGR WCAVHVQIAW QIYRHQQKIK EMQLDPHKLE VGAKLDLFGR PPAPGVFAGF HYPQDLARPL FPSTGAAHPA SNPFGPSAHP GSFLPTGPLT DPFSRPSTFG GLGSLSSHAF GGLGSHALAP GGSIFAPKEG SSVHGLPSPH EAWNRLHRAP PSFPAPPPWP KSVDAERVSA LTNHDREPDN GKEEQERDLL EKTRLLSRAS PATPAGHPVS GLLLRAQSEL GRSGAPAERE AEPRVKESRS PAKEEAAKMP ARASPPHSKA APGDVKVKEE RGEDEASEPP AGGLHPAPLQ LGLGRERLGA PGFAWEPFRG LELPRRAFPA AAPAPGSAAL LEPPERPYRD REPHGYSPER LRGELERARA PHLPPAAPAL DGALLPSLGA LHFPRLSPAA LHNGLLARTP PAAAALGAPP PLVTAAGPPT PPGPPRSRTT PLGGLGPGEA RDYSPSRNPP EVEAR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards