About E3 ubiquitin-protein ligase TRIM39
E3 ubiquitin-protein ligase TRIM39 (TRIM39) is a protein
from Homo sapiens identified by UniProt accession
Q9HCM9, 518 residues long.
MolForge cross-references it against 0 known binders and
53 disease associations.
Target properties
| Protein name | E3 ubiquitin-protein ligase TRIM39 |
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| UniProt accession | Q9HCM9 |
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| Gene | TRIM39 |
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| Organism | Homo sapiens |
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| Length | 518 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (53)
Diseases linked to this target (Open Targets).
- clear cell renal carcinoma · score 0.18
- blood protein measurement · score 0.16
- neutrophil-to-lymphocyte ratio · score 0.14
- BMI-adjusted waist circumference · score 0.13
- risk-taking behaviour · score 0.11
- mosquito bite reaction itch intensity measurement · score 0.10
- renal fibrosis · score 0.07
- chronic obstructive pulmonary disease · score 0.06
- anxiety measurement · score 0.06
- tonsillectomy risk measurement · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9HCM9-F1 | alphafold | PREDICTED | 84.88 | — |
Amino-acid sequence (518 residues)
MAETSLLEAG ASAASTAAAL ENLQVEASCS VCLEYLKEPV IIECGHNFCK ACITRWWEDL ERDFPCPVCR KTSRYRSLRP NRQLGSMVEI AKQLQAVKRK IRDESLCPQH HEALSLFCYE DQEAVCLICA ISHTHRAHTV VPLDDATQEY KEKLQKCLEP LEQKLQEITR CKSSEEKKPG ELKRLVESRR QQILREFEEL HRRLDEEQQV LLSRLEEEEQ DILQRLRENA AHLGDKRRDL AHLAAEVEGK CLQSGFEMLK DVKSTLEKNI PRKFGGSLST ICPRDHKALL GLVKEINRCE KVKTMEVTSV SIELEKNFSN FPRQYFALRK ILKQLIADVT LDPETAHPNL VLSEDRKSVK FVETRLRDLP DTPRRFTFYP CVLATEGFTS GRHYWEVEVG DKTHWAVGVC RDSVSRKGEL TPLPETGYWR VRLWNGDKYA ATTTPFTPLH IKVKPKRVGI FLDYEAGTLS FYNVTDRSHI YTFTDTFTEK LWPLFYPGIR AGRKNAAPLT IRPPTDWE
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