GPN-loop GTPase 1 (GPN1)

About GPN-loop GTPase 1

GPN-loop GTPase 1 (GPN1) is a protein from Homo sapiens identified by UniProt accession Q9HCN4, 374 residues long. MolForge cross-references it against 0 known binders and 58 disease associations.

Target properties

Protein name	GPN-loop GTPase 1
UniProt accession	Q9HCN4
Gene	GPN1
Organism	Homo sapiens
Length	374 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (58)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.39
creatinine measurement · score 0.16
alcohol consumption measurement · score 0.16
systolic blood pressure · score 0.15
hemoglobin measurement · score 0.13
triglyceride measurement · score 0.12
metabolic syndrome · score 0.11
oral cavity cancer · score 0.08
phospholipid measurement · score 0.07
bilirubin measurement · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9HCN4-F1	alphafold	PREDICTED	79.27	—

Amino-acid sequence (374 residues)

MAASAAAAEL QASGGPRHPV CLLVLGMAGS GKTTFVQRLT GHLHAQGTPP YVINLDPAVH EVPFPANIDI RDTVKYKEVM KQYGLGPNGG IVTSLNLFAT RFDQVMKFIE KAQNMSKYVL IDTPGQIEVF TWSASGTIIT EALASSFPTV VIYVMDTSRS TNPVTFMSNM LYACSILYKT KLPFIVVMNK TDIIDHSFAV EWMQDFEAFQ DALNQETTYV SNLTRSMSLV LDEFYSSLRV VGVSAVLGTG LDELFVQVTS AAEEYEREYR PEYERLKKSL ANAESQQQRE QLERLRKDMG SVALDAGTAK DSLSPVLHPS DLILTRGTLD EEDEEADSDT DDIDHRVTEE SHEEPAFQNF MQESMAQYWK RNNK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards