Cytochrome P450 4F12 (CYP4F12)

About Cytochrome P450 4F12

Cytochrome P450 4F12 (CYP4F12) is a protein from Homo sapiens identified by UniProt accession Q9HCS2, 524 residues long. MolForge cross-references it against 0 known binders and 243 disease associations.

Target properties

Protein name	Cytochrome P450 4F12
UniProt accession	Q9HCS2
Gene	CYP4F12
Organism	Homo sapiens
Length	524 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (243)

Diseases linked to this target (Open Targets).

low density lipoprotein cholesterol measurement · score 0.39
total cholesterol measurement · score 0.34
cutaneous melanoma · score 0.23
glioblastoma multiforme · score 0.23
lung adenocarcinoma · score 0.19
endometrial cancer · score 0.16
glioma · score 0.15
urinary bladder cancer · score 0.11
head and neck squamous cell carcinoma · score 0.11
retinitis pigmentosa · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9HCS2-F1	alphafold	PREDICTED	90.77	—

Amino-acid sequence (524 residues)

MSLLSLPWLG LRPVATSPWL LLLLVVGSWL LARILAWTYA FYNNCRRLQC FPQPPKRNWF WGHLGLITPT EEGLKNSTQM SATYSQGFTV WLGPIIPFIV LCHPDTIRSI TNASAAIAPK DNLFIRFLKP WLGEGILLSG GDKWSRHRRM LTPAFHFNIL KSYITIFNKS ANIMLDKWQH LASEGSSRLD MFEHISLMTL DSLQKCIFSF DSHCQERPSE YIATILELSA LVEKRSQHIL QHMDFLYYLS HDGRRFHRAC RLVHDFTDAV IRERRRTLPT QGIDDFFKDK AKSKTLDFID VLLLSKDEDG KALSDEDIRA EADTFMFGGH DTTASGLSWV LYNLARHPEY QERCRQEVQE LLKDRDPKEI EWDDLAQLPF LTMCVKESLR LHPPAPFISR CCTQDIVLPD GRVIPKGITC LIDIIGVHHN PTVWPDPEVY DPFRFDPENS KGRSPLAFIP FSAGPRNCIG QAFAMAEMKV VLALMLLHFR FLPDHTEPRR KLELIMRAEG GLWLRVEPLN VSLQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards