About Band 4.1-like protein 4A
Band 4.1-like protein 4A (EPB41L4A) is a protein
from Homo sapiens identified by UniProt accession
Q9HCS5, 686 residues long.
MolForge cross-references it against 0 known binders and
79 disease associations.
Target properties
| Protein name | Band 4.1-like protein 4A |
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| UniProt accession | Q9HCS5 |
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| Gene | EPB41L4A |
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| Organism | Homo sapiens |
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| Length | 686 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (79)
Diseases linked to this target (Open Targets).
- neurofibrillary tangles measurement · score 0.31
- Abnormality of refraction · score 0.27
- Spastic paraplegia · score 0.26
- Failure to thrive · score 0.26
- DNA methylation · score 0.24
- thyroid carcinoma · score 0.18
- drug use measurement · score 0.14
- hemoglobin measurement · score 0.12
- inflammatory bowel disease · score 0.11
- hematocrit · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9HCS5-F1 | alphafold | PREDICTED | 65.63 | — |
Amino-acid sequence (686 residues)
MGCFCAVPEE FYCEVLLLDE SKLTLTTQQQ GIKKSTKGSV VLDHVFHHVN LVEIDYFGLR YCDRSHQTYW LDPAKTLAEH KELINTGPPY TLYFGIKFYA EDPCKLKEEI TRYQFFLQVK QDVLQGRLPC PVNTAAQLGA YAIQSELGDY DPYKHTAGYV SEYRFVPDQK EELEEAIERI HKTLMGQIPS EAELNYLRTA KSLEMYGVDL HPVYGENKSE YFLGLTPVGV VVYKNKKQVG KYFWPRITKV HFKETQFELR VLGKDCNETS FFFEARSKTA CKHLWKCSVE HHTFFRMPEN ESNSLSRKLS KFGSIRYKHR YSGRTALQMS RDLSIQLPRP DQNVTRSRSK TYPKRIAQTQ PAESNSISRI TANMENGENE GTIKIIAPSP VKSFKKAKNE NSPDTQRSKS HAPWEENGPQ SGLYNSPSDR TKSPKFPYTR RRNPSCGSDN DSVQPVRRRK AHNSGEDSDL KQRRRSRSRC NTSSGSESEN SNREYRKKRN RIRQENDMVD SAPQWEAVLR RQKEKNQADP NNRRSRHRSR SRSPDIQAKE ELWKHIQKEL VDPSGLSEEQ LKEIPYTKIE TQGDPIRIRH SHSPRSYRQY RRSQCSDGER SVLSEVNSKT DLVPPLPVTR SSDAQGSGDA TVHQRRNGSK DSLMEEKPQT STNNLAGKHT AKTIKTIQAS RLKTET
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