About Endosialin
Endosialin (CD248) is a protein
from Homo sapiens identified by UniProt accession
Q9HCU0, 757 residues long.
MolForge cross-references it against 0 known binders and
183 disease associations.
Target properties
| Protein name | Endosialin |
|---|
| UniProt accession | Q9HCU0 |
|---|
| Gene | CD248 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 757 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (183)
Diseases linked to this target (Open Targets).
- vitamin D measurement · score 0.30
- sex hormone-binding globulin measurement · score 0.26
- triglyceride measurement · score 0.24
- self reported educational attainment · score 0.21
- serum gamma-glutamyl transferase measurement · score 0.18
- reticulocyte count · score 0.17
- physical activity measurement · score 0.14
- neoplasm · score 0.13
- genetic disorder · score 0.12
- renal cell carcinoma · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9HCU0-F1 | alphafold | PREDICTED | 63.47 | — |
Amino-acid sequence (757 residues)
MLLRLLLAWA AAGPTLGQDP WAAEPRAACG PSSCYALFPR RRTFLEAWRA CRELGGDLAT PRTPEEAQRV DSLVGAGPAS RLLWIGLQRQ ARQCQLQRPL RGFTWTTGDQ DTAFTNWAQP ASGGPCPAQR CVALEASGEH RWLEGSCTLA VDGYLCQFGF EGACPALQDE AGQAGPAVYT TPFHLVSTEF EWLPFGSVAA VQCQAGRGAS LLCVKQPEGG VGWSRAGPLC LGTGCSPDNG GCEHECVEEV DGHVSCRCTE GFRLAADGRS CEDPCAQAPC EQQCEPGGPQ GYSCHCRLGF RPAEDDPHRC VDTDECQIAG VCQQMCVNYV GGFECYCSEG HELEADGISC SPAGAMGAQA SQDLGDELLD DGEDEEDEDE AWKAFNGGWT EMPGILWMEP TQPPDFALAY RPSFPEDREP QIPYPEPTWP PPLSAPRVPY HSSVLSVTRP VVVSATHPTL PSAHQPPVIP ATHPALSRDH QIPVIAANYP DLPSAYQPGI LSVSHSAQPP AHQPPMISTK YPELFPAHQS PMFPDTRVAG TQTTTHLPGI PPNHAPLVTT LGAQLPPQAP DALVLRTQAT QLPIIPTAQP SLTTTSRSPV SPAHQISVPA ATQPAALPTL LPSQSPTNQT SPISPTHPHS KAPQIPREDG PSPKLALWLP SPAPTAAPTA LGEAGLAEHS QRDDRWLLVA LLVPTCVFLV VLLALGIVYC TRCGPHAPNK RITDCYRWVI HAGSKSPTEP MPPRGSLTGV QTCRTSV
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