Guanine nucleotide-exchange factor SEC12 (PREB)

About Guanine nucleotide-exchange factor SEC12

Guanine nucleotide-exchange factor SEC12 (PREB) is a protein from Homo sapiens identified by UniProt accession Q9HCU5, 417 residues long. MolForge cross-references it against 0 known binders and 27 disease associations.

Target properties

Protein name	Guanine nucleotide-exchange factor SEC12
UniProt accession	Q9HCU5
Gene	PREB
Organism	Homo sapiens
Length	417 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (27)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.55
cutaneous melanoma · score 0.14
lung adenocarcinoma · score 0.12
bilirubin measurement · score 0.02
serum metabolite measurement · score 0.02
infect · score 0.01
infection · score 0.01
fatty liver disease · score 0.01
lung carcinoma · score 0.01
acute lymphoblastic leukemia · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9HCU5-F1	alphafold	PREDICTED	88.09	—

Amino-acid sequence (417 residues)

MGRRRAPELY RAPFPLYALQ VDPSTGLLIA AGGGGAAKTG IKNGVHFLQL ELINGRLSAS LLHSHDTETR ATMNLALAGD ILAAGQDAHC QLLRFQAHQQ QGNKAEKAGS KEQGPRQRKG AAPAEKKCGA ETQHEGLELR VENLQAVQTD FSSDPLQKVV CFNHDNTLLA TGGTDGYVRV WKVPSLEKVL EFKAHEGEIE DLALGPDGKL VTVGRDLKAS VWQKDQLVTQ LHWQENGPTF SSTPYRYQAC RFGQVPDQPA GLRLFTVQIP HKRLRQPPPC YLTAWDGSNF LPLRTKSCGH EVVSCLDVSE SGTFLGLGTV TGSVAIYIAF SLQCLYYVRE AHGIVVTDVA FLPEKGRGPE LLGSHETALF SVAVDSRCQL HLLPSRRSVP VWLLLLLCVG LIIVTILLLQ SAFPGFL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards