DNA polymerase delta subunit 4 (POLD4)

About DNA polymerase delta subunit 4

DNA polymerase delta subunit 4 (POLD4) is a protein from Homo sapiens identified by UniProt accession Q9HCU8, 107 residues long. MolForge cross-references it against 0 known binders and 299 disease associations.

Target properties

Protein name	DNA polymerase delta subunit 4
UniProt accession	Q9HCU8
Gene	POLD4
Organism	Homo sapiens
Length	107 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (299)

Diseases linked to this target (Open Targets).

non-small cell lung carcinoma · score 0.60
acute myeloid leukemia · score 0.60
acute lymphoblastic leukemia · score 0.60
pancreatic carcinoma · score 0.59
chronic lymphocytic leukemia · score 0.59
ovarian carcinoma · score 0.57
breast carcinoma · score 0.57
adult acute lymphoblastic leukemia · score 0.56
leukemia · score 0.56
breast cancer · score 0.56

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9HCU8-F1	alphafold	PREDICTED	84.76	—

Amino-acid sequence (107 residues)

MGRKRLITDS YPVVKRREGP AGHSKGELAP ELGEEPQPRD EEEAELELLR QFDLAWQYGP CTGITRLQRW CRAKQMGLEP PPEVWQVLKT HPGDPRFQCS LWHLYPL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards