About Magnesium transporter MRS2 homolog, mitochondrial
Magnesium transporter MRS2 homolog, mitochondrial (MRS2) is a protein
from Homo sapiens identified by UniProt accession
Q9HD23, 443 residues long.
MolForge cross-references it against 0 known binders and
149 disease associations.
Target properties
| Protein name | Magnesium transporter MRS2 homolog, mitochondrial |
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| UniProt accession | Q9HD23 |
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| Gene | MRS2 |
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| Organism | Homo sapiens |
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| Length | 443 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (149)
Diseases linked to this target (Open Targets).
- alkaline phosphatase measurement · score 0.25
- liver enzyme measurement · score 0.09
- non-alcoholic steatohepatitis · score 0.08
- Hepatic fibrosis · score 0.06
- non-alcoholic fatty liver disease · score 0.06
- glomerular filtration rate · score 0.06
- insulin resistance · score 0.05
- mean corpuscular hemoglobin · score 0.04
- hepatocellular carcinoma · score 0.03
- miotic rate · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9HD23-F1 | alphafold | PREDICTED | 71.06 | — |
Amino-acid sequence (443 residues)
MECLRSLPCL LPRAMRLPRR TLCALALDVT SVGPPVAACG RRANLIGRSR AAQLCGPDRL RVAGEVHRFR TSDVSQATLA SVAPVFTVTK FDKQGNVTSF ERKKTELYQE LGLQARDLRF QHVMSITVRN NRIIMRMEYL KAVITPECLL ILDYRNLNLE QWLFRELPSQ LSGEGQLVTY PLPFEFRAIE ALLQYWINTL QGKLSILQPL ILETLDALVD PKHSSVDRSK LHILLQNGKS LSELETDIKI FKESILEILD EEELLEELCV SKWSDPQVFE KSSAGIDHAE EMELLLENYY RLADDLSNAA RELRVLIDDS QSIIFINLDS HRNVMMRLNL QLTMGTFSLS LFGLMGVAFG MNLESSLEED HRIFWLITGI MFMGSGLIWR RLLSFLGRQL EAPLPPMMAS LPKKTLLADR SMELKNSLRL DGLGSGRSIL TNR
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