About Golgi-associated PDZ and coiled-coil motif-containing protein
Golgi-associated PDZ and coiled-coil motif-containing protein (GOPC) is a protein
from Homo sapiens identified by UniProt accession
Q9HD26, 462 residues long.
MolForge cross-references it against 0 known binders and
216 disease associations.
Target properties
| Protein name | Golgi-associated PDZ and coiled-coil motif-containing protein |
|---|
| UniProt accession | Q9HD26 |
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| Gene | GOPC |
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| Organism | Homo sapiens |
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| Length | 462 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (216)
Diseases linked to this target (Open Targets).
- systolic blood pressure · score 0.39
- non-small cell lung carcinoma · score 0.37
- hepatocellular carcinoma · score 0.37
- bile duct adenocarcinoma · score 0.37
- brain astrocytoma · score 0.37
- body height · score 0.34
- apolipoprotein A 1 measurement · score 0.31
- neurodegenerative disease · score 0.28
- lung adenocarcinoma · score 0.28
- Borderline Ovarian Serous Tumor · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9HD26-F1 | alphafold | PREDICTED | 69.12 | — |
Amino-acid sequence (462 residues)
MSAGGPCPAA AGGGPGGASC SVGAPGGVSM FRWLEVLEKE FDKAFVDVDL LLGEIDPDQA DITYEGRQKM TSLSSCFAQL CHKAQSVSQI NHKLEAQLVD LKSELTETQA EKVVLEKEVH DQLLQLHSIQ LQLHAKTGQS ADSGTIKAKL SGPSVEELER ELEANKKEKM KEAQLEAEVK LLRKENEALR RHIAVLQAEV YGARLAAKYL DKELAGRVQQ IQLLGRDMKG PAHDKLWNQL EAEIHLHRHK TVIRACRGRN DLKRPMQAPP GHDQDSLKKS QGVGPIRKVL LLKEDHEGLG ISITGGKEHG VPILISEIHP GQPADRCGGL HVGDAILAVN GVNLRDTKHK EAVTILSQQR GEIEFEVVYV APEVDSDDEN VEYEDESGHR YRLYLDELEG GGNPGASCKD TSGEIKVLQG FNKKAVTDTH ENGDLGTASE TPLDDGASKL DDLHTLYHKK SY
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