About O-phosphoseryl-tRNA(Sec) selenium transferase
O-phosphoseryl-tRNA(Sec) selenium transferase (SEPSECS) is a protein
from Homo sapiens identified by UniProt accession
Q9HD40, 501 residues long.
MolForge cross-references it against 0 known binders and
84 disease associations.
Target properties
| Protein name | O-phosphoseryl-tRNA(Sec) selenium transferase |
|---|
| UniProt accession | Q9HD40 |
|---|
| Gene | SEPSECS |
|---|
| Organism | Homo sapiens |
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| Length | 501 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (84)
Diseases linked to this target (Open Targets).
- pontocerebellar hypoplasia type 2 · score 0.78
- pontocerebellar hypoplasia · score 0.57
- neurodegenerative disease · score 0.54
- genetic disorder · score 0.50
- Non-syndromic pontocerebellar hypoplasia · score 0.44
- progressive cerebello-cerebral atrophy · score 0.37
- spastic ataxia · score 0.34
- tonsillectomy risk measurement · score 0.32
- blood protein measurement · score 0.31
- Kyphosis · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9HD40-F1 | alphafold | PREDICTED | 92.80 | — |
Amino-acid sequence (501 residues)
MNRESFAAGE RLVSPAYVRQ GCEARRSHEH LIRLLLEKGK CPENGWDEST LELFLHELAI MDSNNFLGNC GVGEREGRVA SALVARRHYR FIHGIGRSGD ISAVQPKAAG SSLLNKITNS LVLDIIKLAG VHTVANCFVV PMATGMSLTL CFLTLRHKRP KAKYIIWPRI DQKSCFKSMI TAGFEPVVIE NVLEGDELRT DLKAVEAKVQ ELGPDCILCI HSTTSCFAPR VPDRLEELAV ICANYDIPHI VNNAYGVQSS KCMHLIQQGA RVGRIDAFVQ SLDKNFMVPV GGAIIAGFND SFIQEISKMY PGRASASPSL DVLITLLSLG SNGYKKLLKE RKEMFSYLSN QIKKLSEAYN ERLLHTPHNP ISLAMTLKTL DEHRDKAVTQ LGSMLFTRQV SGARVVPLGS MQTVSGYTFR GFMSHTNNYP CAYLNAASAI GMKMQDVDLF IKRLDRCLKA VRKERSKESD DNYDKTEDVD IEEMALKLDN VLLDTYQDAS S
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