About Transmembrane 9 superfamily member 3
Transmembrane 9 superfamily member 3 (TM9SF3) is a protein
from Homo sapiens identified by UniProt accession
Q9HD45, 589 residues long.
MolForge cross-references it against 0 known binders and
47 disease associations.
Target properties
| Protein name | Transmembrane 9 superfamily member 3 |
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| UniProt accession | Q9HD45 |
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| Gene | TM9SF3 |
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| Organism | Homo sapiens |
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| Length | 589 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (47)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.42
- lymphocyte count · score 0.24
- lymphocyte:monocyte ratio · score 0.20
- platelet-to-lymphocyte ratio · score 0.16
- lymphocyte percentage of leukocytes · score 0.12
- monocyte count · score 0.11
- monocyte percentage of leukocytes · score 0.06
- uncombable hair syndrome · score 0.04
- hypertriglyceridemia 2 · score 0.04
- Lipedema · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9HD45-F1 | alphafold | PREDICTED | 86.57 | — |
Amino-acid sequence (589 residues)
MRPLPGALGV AAAAALWLLL LLLPRTRADE HEHTYQDKEE VVLWMNTVGP YHNRQETYKY FSLPFCVGSK KSISHYHETL GEALQGVELE FSGLDIKFKD DVMPATYCEI DLDKEKRDAF VYAIKNHYWY QMYIDDLPIW GIVGEADENG EDYYLWTYKK LEIGFNGNRI VDVNLTSEGK VKLVPNTKIQ MSYSVKWKKS DVKFEDRFDK YLDPSFFQHR IHWFSIFNSF MMVIFLVGLV SMILMRTLRK DYARYSKEEE MDDMDRDLGD EYGWKQVHGD VFRPSSHPLI FSSLIGSGCQ IFAVSLIVII VAMIEDLYTE RGSMLSTAIF VYAATSPVNG YFGGSLYARQ GGRRWIKQMF IGAFLIPAMV CGTAFFINFI AIYYHASRAI PFGTMVAVCC ICFFVILPLN LVGTILGRNL SGQPNFPCRV NAVPRPIPEK KWFMEPAVIV CLGGILPFGS IFIEMYFIFT SFWAYKIYYV YGFMMLVLVI LCIVTVCVTI VCTYFLLNAE DYRWQWTSFL SAASTAIYVY MYSFYYYFFK TKMYGLFQTS FYFGYMAVFS TALGIMCGAI GYMGTSAFVR KIYTNVKID
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