About Ran guanine nucleotide release factor
Ran guanine nucleotide release factor (RANGRF) is a protein
from Homo sapiens identified by UniProt accession
Q9HD47, 186 residues long.
MolForge cross-references it against 0 known binders and
87 disease associations.
Target properties
| Protein name | Ran guanine nucleotide release factor |
|---|
| UniProt accession | Q9HD47 |
|---|
| Gene | RANGRF |
|---|
| Organism | Homo sapiens |
|---|
| Length | 186 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (87)
Diseases linked to this target (Open Targets).
- cardiac arrhythmia · score 0.20
- Immature Reticulocyte Fraction Measurement · score 0.20
- reticulocyte count · score 0.20
- leukocyte count · score 0.14
- myeloid white cell count · score 0.06
- hypertrophic cardiomyopathy · score 0.06
- HbA1c measurement · score 0.06
- erythrocyte count · score 0.05
- Arrhythmogenic right ventricular dysplasia · score 0.05
- Glycogen storage disease due to glycogenin deficiency · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9HD47-F1 | alphafold | PREDICTED | 78.03 | — |
Amino-acid sequence (186 residues)
MEPTRDCPLF GGAFSAILPM GAIDVSDLRP VPDNQEVFCH PVTDQSLIVE LLELQAHVRG EAAARYHFED VGGVQGARAV HVESVQPLSL ENLALRGRCQ EAWVLSGKQQ IAKENQQVAK DVTLHQALLR LPQYQTDLLL TFNQPPPDNR SSLGPENLSP APWSLGDFEQ LVTSLTLHDP NIFGPQ
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