Neurexin-3-beta (NRXN3)

About Neurexin-3-beta

Neurexin-3-beta (NRXN3) is a protein from Homo sapiens identified by UniProt accession Q9HDB5, 637 residues long. MolForge cross-references it against 0 known binders and 138 disease associations.

Target properties

Protein name	Neurexin-3-beta
UniProt accession	Q9HDB5
Gene	NRXN3
Organism	Homo sapiens
Length	637 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (138)

Diseases linked to this target (Open Targets).

body mass index · score 0.50
lean body mass · score 0.48
physical activity measurement · score 0.47
body fat percentage · score 0.47
type 2 diabetes mellitus · score 0.46
fat body mass · score 0.45
obesity · score 0.44
smoking behavior · score 0.44
body weight · score 0.43
waist circumference · score 0.43

3D Structure

Predicted structure for Q9HDB5 is available from the AlphaFold Protein Structure Database.

Amino-acid sequence (637 residues)

MHLRIHARRS PPRRPAWTLG IWFLFWGCIV SSVWSSSNVA SSSSTSSSPG SHSQHEHHFH GSKHHSVPIS IYRSPVSLRG GHAGATYIFG KSGGLILYTW PANDRPSTRS DRLAVGFSTT VKDGILVRID SAPGLGDFLQ LHIEQGKIGV VFNIGTVDIS IKEERTPVND GKYHVVRFTR NGGNATLQVD NWPVNEHYPT GRQLTIFNTQ AQIAIGGKDK GRLFQGQLSG LYYDGLKVLN MAAENNPNIK INGSVRLVGE VPSILGTTQT TSMPPEMSTT VMETTTTMAT TTTRKNRSTA SIQPTSDDLV SSAECSSDDE DFVECEPSTG GELVIPLLVE DPLATPPIAT RAPSITLPPT FRPLLTIIET TKDSLSMTSE AGLPCLSDQG SDGCDDDGLV ISGYGSGETF DSNLPPTDDE DFYTTFSLVT DKSLSTSIFE GGYKAHAPKW ESKDFRPNKV SETSRTTTTS LSPELIRFTA SSSSGMVPKL PAGKMNNRDL KPQPDIVLLP LPTAYELDST KLKSPLITSP MFRNVPTANP TEPGIRRVPG ASEVIRESSS TTGMVVGIVA AAALCILILL YAMYKYRNRD EGSYQVDETR NYISNSAQSN GTLMKEKQQS SKSGHKKQKN KDREYYV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards