Homeobox protein HMX1 (HMX1)

About Homeobox protein HMX1

Homeobox protein HMX1 (HMX1) is a protein from Homo sapiens identified by UniProt accession Q9NP08, 348 residues long. MolForge cross-references it against 0 known binders and 42 disease associations.

Target properties

Protein name	Homeobox protein HMX1
UniProt accession	Q9NP08
Gene	HMX1
Organism	Homo sapiens
Length	348 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (42)

Diseases linked to this target (Open Targets).

oculoauricular syndrome · score 0.76
neurodegenerative disease · score 0.52
Oculoauricular syndrome, Schorderet type · score 0.46
Isolated anophthalmia - microphthalmia · score 0.34
blood protein measurement · score 0.19
genetic disorder · score 0.19
deafness-ear malformation-facial palsy syndrome · score 0.03
thickened earlobes-conductive deafness syndrome · score 0.03
Thickened earlobes - conductive deafness · score 0.03
urate measurement · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NP08-F1	alphafold	PREDICTED	61.75	—

Amino-acid sequence (348 residues)

MPDELTEPGR ATPARASSFL IENLLAAEAK GAGRATQGDG SREDEEEDDD DPEDEDAEQA RRRRLQRRRQ LLAGTGPGGE ARARALLGPG ALGLGPRPPP GPGPPFALGC GGAARWYPRA HGGYGGGLSP DTSDRDSPET GEEMGRAEGA WPRGPGPGAV QREAAELAAR GPAAGTEEAS ELAEVPAAAG ETRGGVGVGG GRKKKTRTVF SRSQVFQLES TFDLKRYLSS AERAGLAASL QLTETQVKIW FQNRRNKWKR QLAAELEAAS LSPPGAQRLV RVPVLYHESP PAAAAAGPPA TLPFPLAPAA PAPPPPLLGF SGALAYPLAA FPAAASVPFL RAQMPGLV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards