About SIN3-HDAC complex-associated factor
SIN3-HDAC complex-associated factor (SINHCAF) is a protein
from Homo sapiens identified by UniProt accession
Q9NP50, 221 residues long.
MolForge cross-references it against 0 known binders and
70 disease associations.
Target properties
| Protein name | SIN3-HDAC complex-associated factor |
|---|
| UniProt accession | Q9NP50 |
|---|
| Gene | SINHCAF |
|---|
| Organism | Homo sapiens |
|---|
| Length | 221 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (70)
Diseases linked to this target (Open Targets).
- type 2 diabetes mellitus · score 0.41
- body mass index · score 0.34
- body weight · score 0.33
- hemoglobin A1 measurement · score 0.32
- HbA1c measurement · score 0.29
- blood protein measurement · score 0.26
- grey matter volume measurement · score 0.10
- C-reactive protein measurement · score 0.07
- osteosarcoma · score 0.07
- neoplasm · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NP50-F1 | alphafold | PREDICTED | 72.66 | — |
Amino-acid sequence (221 residues)
MFGFHKPKMY RSIEGCCICR AKSSSSRFTD SKRYEKDFQS CFGLHETRSG DICNACVLLV KRWKKLPAGS KKNWNHVVDA RAGPSLKTTL KPKKVKTLSG NRIKSNQISK LQKEFKRHNS DAHSTTSSAS PAQSPCYSNQ SDDGSDTEMA SGSNRTPVFS FLDLTYWKRQ KICCGIIYKG RFGEVLIDTH LFKPCCSNKK AAAEKPEEQG PEPLPISTQE W
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