About X-linked interleukin-1 receptor accessory protein-like 2
X-linked interleukin-1 receptor accessory protein-like 2 (IL1RAPL2) is a protein
from Homo sapiens identified by UniProt accession
Q9NP60, 686 residues long.
MolForge cross-references it against 0 known binders and
17 disease associations.
Target properties
| Protein name | X-linked interleukin-1 receptor accessory protein-like 2 |
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| UniProt accession | Q9NP60 |
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| Gene | IL1RAPL2 |
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| Organism | Homo sapiens |
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| Length | 686 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (17)
Diseases linked to this target (Open Targets).
- central nervous system cancer · score 0.03
- non-small cell lung carcinoma · score 0.03
- body weight · score 0.03
- thyroxine measurement · score 0.03
- blood protein measurement · score 0.02
- triiodothyronine measurement · score 0.02
- primary biliary cirrhosis · score 0.01
- hepatocellular carcinoma · score 0.01
- Autism · score 0.00
- viral disease · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NP60-F1 | alphafold | PREDICTED | 75.15 | — |
Amino-acid sequence (686 residues)
MKPPFLLALV VCSVVSTNLK MVSKRNSVDG CIDWSVDLKT YMALAGEPVR VKCALFYSYI RTNYSTAQST GLRLMWYKNK GDLEEPIIFS EVRMSKEEDS IWFHSAEAQD SGFYTCVLRN STYCMKVSMS LTVAENESGL CYNSRIRYLE KSEVTKRKEI SCPDMDDFKK SDQEPDVVWY KECKPKMWRS IIIQKGNALL IQEVQEEDGG NYTCELKYEG KLVRRTTELK VTALLTDKPP KPLFPMENQP SVIDVQLGKP LNIPCKAFFG FSGESGPMIY WMKGEKFIEE LAGHIREGEI RLLKEHLGEK EVELALIFDS VVEADLANYT CHVENRNGRK HASVLLRKKD LIYKIELAGG LGAIFLLLVL LVVIYKCYNI ELMLFYRQHF GADETNDDNK EYDAYLSYTK VDQDTLDCDN PEEEQFALEV LPDVLEKHYG YKLFIPERDL IPSGTYMEDL TRYVEQSRRL IIVLTPDYIL RRGWSIFELE SRLHNMLVSG EIKVILIECT ELKGKVNCQE VESLKRSIKL LSLIKWKGSK SSKLNSKFWK HLVYEMPIKK KEMLPRCHVL DSAEQGLFGE LQPIPSIAMT STSATLVSSQ ADLPEFHPSD SMQIRHCCRG YKHEIPATTL PVPSLGNHHT YCNLPLTLLN GQLPLNNTLK DTQEFHRNSS LLPLSSKELS FTSDIW
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