About ADP-ribosylation factor GTPase-activating protein 3
ADP-ribosylation factor GTPase-activating protein 3 (ARFGAP3) is a protein
from Homo sapiens identified by UniProt accession
Q9NP61, 516 residues long.
MolForge cross-references it against 0 known binders and
28 disease associations.
Target properties
| Protein name | ADP-ribosylation factor GTPase-activating protein 3 |
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| UniProt accession | Q9NP61 |
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| Gene | ARFGAP3 |
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| Organism | Homo sapiens |
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| Length | 516 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (28)
Diseases linked to this target (Open Targets).
- body height · score 0.27
- platelet component distribution width · score 0.24
- sitting height measurement · score 0.15
- platelet-to-lymphocyte ratio · score 0.12
- primary ovarian insufficiency · score 0.12
- reticulocyte count · score 0.11
- breast adenocarcinoma · score 0.10
- mean platelet volume · score 0.09
- blood protein measurement · score 0.09
- self reported educational attainment · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NP61-F1 | alphafold | PREDICTED | 65.71 | — |
Amino-acid sequence (516 residues)
MGDPSKQDIL TIFKRLRSVP TNKVCFDCGA KNPSWASITY GVFLCIDCSG SHRSLGVHLS FIRSTELDSN WSWFQLRCMQ VGGNASASSF FHQHGCSTND TNAKYNSRAA QLYREKIKSL ASQATRKHGT DLWLDSCVVP PLSPPPKEED FFASHVSPEV SDTAWASAIA EPSSLTSRPV ETTLENNEGG QEQGPSVEGL NVPTKATLEV SSIIKKKPNQ AKKGLGAKKG SLGAQKLANT CFNEIEKQAQ AADKMKEQED LAKVVSKEES IVSSLRLAYK DLEIQMKKDE KMNISGKKNV DSDRLGMGFG NCRSVISHSV TSDMQTIEQE SPIMAKPRKK YNDDSDDSYF TSSSSYFDEP VELRSSSFSS WDDSSDSYWK KETSKDTETV LKTTGYSDRP TARRKPDYEP VENTDEAQKK FGNVKAISSD MYFGRQSQAD YETRARLERL SASSSISSAD LFEEPRKQPA GNYSLSSVLP NAPDMAQFKQ GVRSVAGKLS VFANGVVTSI QDRYGS
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