Chorion-specific transcription factor GCMa (GCM1)

About Chorion-specific transcription factor GCMa

Chorion-specific transcription factor GCMa (GCM1) is a protein from Homo sapiens identified by UniProt accession Q9NP62, 436 residues long. MolForge cross-references it against 0 known binders and 45 disease associations.

Target properties

Protein name	Chorion-specific transcription factor GCMa
UniProt accession	Q9NP62
Gene	GCM1
Organism	Homo sapiens
Length	436 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (45)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.34
folate deficiency · score 0.07
fetal growth restriction · score 0.07
HbA1c measurement · score 0.03
age at first sexual intercourse measurement · score 0.02
mean reticulocyte volume · score 0.02
mean platelet volume · score 0.02
lymphocyte count · score 0.02
preeclampsia · score 0.02
placenta disease · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NP62-F1	alphafold	PREDICTED	60.48	—

Amino-acid sequence (436 residues)

MEPDDFDSED KEILSWDIND VKLPQNVKKT DWFQEWPDSY AKHIYSSEDK NAQRHLSSWA MRNTNNHNSR ILKKSCLGVV VCGRDCLAEE GRKIYLRPAI CDKARQKQQR KRCPNCDGPL KLIPCRGHGG FPVTNFWRHD GRFIFFQSKG EHDHPKPETK LEAEARRAMK KVNTAPSSVS LSLKGSTETR SLPGETQSQG SLPLTWSFQE GVQLPGSYSG HLIANTPQQN SLNDCFSFSK SYGLGGITDL TDQTSTVDPM KLYEKRKLSS SRTYSSGDLL PPSASGVYSD HGDLQAWSKN AALGRNHLAD NCYSNYPFPL TSWPCSFSPS QNSSEPFYQQ LPLEPPAAKT GCPPLWPNPA GNLYEEKVHV DFNSYVQSPA YHSPQEDPFL FTYASHPHQQ YSLPSKSSKW DFEEEMTYLG LDHCNNDMLL NLCPLR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards