About Carbohydrate-responsive element-binding protein
Carbohydrate-responsive element-binding protein (MLXIPL) is a protein
from Homo sapiens identified by UniProt accession
Q9NP71, 852 residues long.
MolForge cross-references it against 0 known binders and
299 disease associations.
Target properties
| Protein name | Carbohydrate-responsive element-binding protein |
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| UniProt accession | Q9NP71 |
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| Gene | MLXIPL |
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| Organism | Homo sapiens |
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| Length | 852 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (299)
Diseases linked to this target (Open Targets).
- triglyceride measurement · score 0.49
- reticulocyte count · score 0.41
- serum gamma-glutamyl transferase measurement · score 0.41
- alkaline phosphatase measurement · score 0.40
- phosphatidylcholine measurement · score 0.39
- high density lipoprotein cholesterol measurement · score 0.39
- low density lipoprotein cholesterol measurement · score 0.39
- alcohol consumption measurement · score 0.39
- sphingomyelin measurement · score 0.39
- sex hormone-binding globulin measurement · score 0.38
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NP71-F1 | alphafold | PREDICTED | 53.85 | — |
Amino-acid sequence (852 residues)
MAGALAGLAA GLQVPRVAPS PDSDSDTDSE DPSLRRSAGG LLRSQVIHSG HFMVSSPHSD SLPRRRDQEG SVGPSDFGPR SIDPTLTRLF ECLSLAYSGK LVSPKWKNFK GLKLLCRDKI RLNNAIWRAW YIQYVKRRKS PVCGFVTPLQ GPEADAHRKP EAVVLEGNYW KRRIEVVMRE YHKWRIYYKK RLRKPSREDD LLAPKQAEGR WPPPEQWCKQ LFSSVVPVLL GDPEEEPGGR QLLDLNCFLS DISDTLFTMT QSGPSPLQLP PEDAYVGNAD MIQPDLTPLQ PSLDDFMDIS DFFTNSRLPQ PPMPSNFPEP PSFSPVVDSL FSSGTLGPEV PPASSAMTHL SGHSRLQARN SCPGPLDSSA FLSSDFLLPE DPKPRLPPPP VPPPLLHYPP PAKVPGLEPC PPPPFPPMAP PTALLQEEPL FSPRFPFPTV PPAPGVSPLP APAAFPPTPQ SVPSPAPTPF PIELLPLGYS EPAFGPCFSM PRGKPPAPSP RGQKASPPTL APATASPPTT AGSNNPCLTQ LLTAAKPEQA LEPPLVSSTL LRSPGSPQET VPEFPCTFLP PTPAPTPPRP PPGPATLAPS RPLLVPKAER LSPPAPSGSE RRLSGDLSSM PGPGTLSVRV SPPQPILSRG RPDSNKTENR RITHISAEQK RRFNIKLGFD TLHGLVSTLS AQPSLKVSKA TTLQKTAEYI LMLQQERAGL QEEAQQLRDE IEELNAAINL CQQQLPATGV PITHQRFDQM RDMFDDYVRT RTLHNWKFWV FSILIRPLFE SFNGMVSTAS VHTLRQTSLA WLDQYCSLPA LRPTVLNSLR QLGTSTSILT DPGRIPEQAT RAVTEGTLGK PL
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